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Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study
Silva, Barbara Barduchi Oliveira da; Silva Júnior, Moacyr; Menezes, Fernando Gatti de; Troster, Eduardo Juan.
  • Silva, Barbara Barduchi Oliveira da; Hospital Israelita Albert Einstein. São Paulo. BR
  • Silva Júnior, Moacyr; Hospital Israelita Albert Einstein. São Paulo. BR
  • Menezes, Fernando Gatti de; Hospital Israelita Albert Einstein. São Paulo. BR
  • Troster, Eduardo Juan; Hospital Israelita Albert Einstein. São Paulo. BR
Einstein (Säo Paulo) ; 20: eAO6704, 2022. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1375338
ABSTRACT
ABSTRACT Objective To investigate the prevalence of factors related to healthcare-associated infections, caused by multidrug-resistant bacteria, in a pediatric intensive care unit. Methods A retrospective case-control study conducted from January 1, 2007 to December 31, 2018, in São Paulo (SP), Brazil. The study was carried out at the pediatric intensive care unit of a high-complexity, tertiary care general hospital. The study included patients aged 1 month to 19 years, admitted to the pediatric intensive care unit, diagnosed as healthcare-associated infections. Results There was significant evidence of infection by multidrug-resistant bacteria associated with immunosuppressed patients (p<0.001), in whom the likelihood of multidrug-resistant bacteria infection was estimated to be nine-fold higher than among non-immunosuppressed patients (OR 8.97; 95%CI 2.69-29.94). In the analysis of multiple logistic regression model, we observed that immunosuppressed patients had an 8.5-fold higher chance of multidrug-resistant bacteria infection when compared to non-immunosuppressed patients (OR 8.48; 95%CI 2.54-28.35; p=0.001). There is evidence of association between the Case Group and presence of Gram-positive (p=0.007), coagulase-negative Staphylococcus (p<0.001), and Gram-negative (p=0.041) microorganisms. Conclusion The immunocompromised-state variable is a factor related to healthcare-associated infections caused by multidrug-resistant bacteria, and the Case Group presented higher proportions of Gram-positive microorganisms and coagulase-negative Staphylococcus.


Full text: Available Index: LILACS (Americas) Type of study: Observational study / Prognostic study / Risk factors Language: English Journal: Einstein (Säo Paulo) Journal subject: Medicine Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Israelita Albert Einstein/BR

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Full text: Available Index: LILACS (Americas) Type of study: Observational study / Prognostic study / Risk factors Language: English Journal: Einstein (Säo Paulo) Journal subject: Medicine Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Israelita Albert Einstein/BR