The translational challenge in Chagas disease drug development
Mem. Inst. Oswaldo Cruz
;
117: e200501, 2022. graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1375909
ABSTRACT
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations. Drug development for Chagas disease has historically been hampered by the complexity of the disease, critical knowledge gaps, and lack of coordinated R&D efforts. This review covers some of the translational challenges associated with the progression of new chemical entities from preclinical to clinical phases of development, and discusses how recent technological advances might allow the research community to answer key questions relevant to the disease and to overcome hurdles in R&D for Chagas disease.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Prognostic study
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2022
Type:
Article
/
Project document
Affiliation country:
Brazil
/
Switzerland
Institution/Affiliation country:
Drugs for Neglected Diseases initiative/CH
/
Universidade Federal de São Paulo/BR
/
Universidade de São Paulo/BR
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