Parasitological, serological and molecular diagnosis of acute and chronic Chagas disease: from field to laboratory
Mem. Inst. Oswaldo Cruz
;
117: e200444, 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1375921
ABSTRACT
There is no consensus on the diagnostic algorithms for many scenarios of Trypanosoma cruzi infection, which hinders the establishment of governmental guidelines in endemic and non-endemic countries. In the acute phase, parasitological methods are currently employed, and standardised surrogate molecular tests are being introduced to provide higher sensitivity and less operator-dependence. In the chronic phase, IgG-based serological assays are currently used, but if a single assay does not reach the required accuracy, PAHO/WHO recommends at least two immunological tests with different technical principles. Specific algorithms are applied to diagnose congenital infection, screen blood and organ donors or conduct epidemiological surveys. Detecting Chagas disease reactivation in immunosuppressed individuals is an area of increasing interest. Due to its neglect, enhancing access to diagnosis of patients at risk of suffering T. cruzi infection should be a priority at national and regional levels.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Diagnostic study
/
Practice guideline
/
Qualitative research
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2022
Type:
Article
Affiliation country:
Argentina
/
Spain
/
Switzerland
Institution/Affiliation country:
Barcelona Institute for Global Health/ES
/
Foundation for Innovative New Diagnostics/CH
/
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular Dr Hector Torres/AR
Similar
MEDLINE
...
LILACS
LIS