Your browser doesn't support javascript.
loading
Lung cancer screening in clinical practice: identification of high-risk chronic obstructive pulmonary disease patients
Sousa, Sofia Rodrigues; Caldeira, João Nunes; Rodrigues, Cidália; Figueiredo, Ana; Barata, Fernando.
  • Sousa, Sofia Rodrigues; Coimbra University Hospital. Pulmonology Department. Coimbra. PT
  • Caldeira, João Nunes; Coimbra University Hospital. Pulmonology Department. Coimbra. PT
  • Rodrigues, Cidália; Coimbra University Hospital. Pulmonology Department. Coimbra. PT
  • Figueiredo, Ana; Coimbra University Hospital. Pulmonology Department. Coimbra. PT
  • Barata, Fernando; Coimbra University Hospital. Pulmonology Department. Coimbra. PT
Rev. Assoc. Med. Bras. (1992) ; 68(4): 502-506, Apr. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1376148
ABSTRACT
SUMMARY

OBJECTIVE:

The NELSON study demonstrated a positive association between computed tomography scanning and reduced mortality associated with lung cancer. The COPD-LUCSS-DLCO is a tool designed to improve screening selection criteria of lung cancer for chronic obstructive pulmonary disease patients. The aim of this study was to examine and compare the discriminating value of both scores in a community-based cohort of chronic obstructive pulmonary disease patients.

METHODS:

A retrospective study of chronic obstructive pulmonary disease patients followed in pulmonology consultation for a period of 10 years (2009-2019) was conducted. The NELSON criteria and COPD-LUCSS-DLCO score were calculated for each patient at the time of the study inclusion. The lung cancer incidence was calculated for each of the subgroups during the follow-up period.

RESULTS:

A total of 103 patients were included in the study (mean age 64.7±9.2 years, 88.3% male). Applying the COPD-LUCSS-DLCO score, high-risk patients have a 5.9-fold greater risk of developing lung cancer versus the low risk. In contrast, there was no significant association between NELSON selection criteria and lung cancer incidence. The area under the curve was 0.69 for COPD-LUCSS-DLCO and 0.59 for NELSON criteria. Comparing test results showed no differences.

CONCLUSIONS:

The use of the COPD-LUCSS-DLCO score in clinical practice can help to detect chronic obstructive pulmonary disease patients in greater risk of developing lung cancer with better performance than NELSON criteria. Therefore, models that include a risk biomarker strategy can improve selection criteria and consequently can enhance a better lung cancer prediction.


Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors / Screening study Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2022 Type: Article Affiliation country: Portugal Institution/Affiliation country: Coimbra University Hospital/PT

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors / Screening study Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2022 Type: Article Affiliation country: Portugal Institution/Affiliation country: Coimbra University Hospital/PT