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Dramatic secukinumab-mediated improvements in refractory leprosy-related neuritis via the modulation of T helper 1 (Th1) and T helper 17 (Th17) immune pathways
Kurizky, Patrícia Shu; Motta, Jorgeth de Oliveira Carneiro da; Bezerra, Natanael Victor Furtunato; Sousa, Marcia Carolline dos Santos; Corazza, Danilo; Borges, Tatiana Karla dos Santos; Gomes, Ciro Martins.
  • Kurizky, Patrícia Shu; Universidade de Brasília. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas. Brasília. BR
  • Motta, Jorgeth de Oliveira Carneiro da; Universidade de Brasília. Faculdade de Medicina. Hospital Universitário de Brasília. Brasília. BR
  • Bezerra, Natanael Victor Furtunato; Universidade de Brasília. Faculdade de Medicina. Hospital Universitário de Brasília. Brasília. BR
  • Sousa, Marcia Carolline dos Santos; Universidade de Brasília. Faculdade de Medicina. Hospital Universitário de Brasília. Brasília. BR
  • Corazza, Danilo; Universidade de Brasília. Núcleo de Medicina Tropical. Programa de Pós-Graduação em Medicina Tropical. Brasília. BR
  • Borges, Tatiana Karla dos Santos; Universidade de Brasília. Núcleo de Medicina Tropical. Programa de Pós-Graduação em Medicina Tropical. Brasília. BR
  • Gomes, Ciro Martins; Universidade de Brasília. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas. Brasília. BR
Rev. Soc. Bras. Med. Trop ; 54: e03362021, 2021. graf
Article in English | LILACS | ID: biblio-1376337
ABSTRACT
Abstract A 39-year-old woman was diagnosed with relapsed multibacillary leprosy and refractory neuritis. Here, we describe an evident loss of therapeutic effectiveness after the third pulse of corticosteroids, which may be attributed to tachyphylaxis and the posterior modulation of interferon- γ (IFN-γ), tumor necrosis factor- α (TNF-α,) interleukin-17A (IL-17A), and IL-12/23p40 after the induction phase of secukinumab. In this case, plasma cytokine analysis showed that secukinumab induced a reduction in IL-17 concomitant with impressive clinical improvements in the patient's neural function. Interestingly, secukinumab induced reductions in cytokines related to Th1 responses and earlier stages of the Th17 response, including IL-23/12.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Antibodies, Monoclonal, Humanized / Leprosy / Neuritis Limits: Adult / Female / Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Brasília/BR

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Full text: Available Index: LILACS (Americas) Main subject: Antibodies, Monoclonal, Humanized / Leprosy / Neuritis Limits: Adult / Female / Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Brasília/BR