Pediatric Heart Transplant: Initial Experience in a Tertiary Center in Brazil
Rev. bras. cir. cardiovasc
;
37(3): 281-291, May-June 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1376534
ABSTRACT
ABSTRACT Introduction:
Pediatric heart transplantation is the definitive therapy for children with end-stage heart failure. This paper describes our initial experience in pediatric heart transplantation in a tertiary center in BrazilMethods:
This is a historical prospective descriptive cohort study based on a review of the medical records of children undergoing heart transplantation at Hospital de Base and Hospital da Criança e Maternidade de São José do Rio Preto. Variables were displayed as frequency, mean, or median. Statistical analysis and Kaplan-Meier actuarial curve were obtained with the aid of Microsoft® Excel® 2019 and STATSDirect version 3.3.5.Results:
Between January 2010 and December 2020, ten children underwent bicaval orthotopic heart transplantation, 30% of which were under one year of age. Nine patients had end-stage heart failure (International Society for Heart and Lung Transplantation-Heart Failure D) and 50% of the recipients were transplanted under conditions of progressive clinical deterioration (Interagency Registry for Mechanically Assisted Circulatory Support ≤ 2). Forty percent of the recipients had a panel-reactive antibody > 20% on virtual crossmatch. In the postoperative period, 80% of patients required high dose of inotropic support (vasoactive-inotropic score > 10) for > 48 hours. The death-free survival rate at 131 months was 77.1±14.4%. Most patients (88.9%) in late follow-up had an episode of active cytomegalovirus infection. Cellular rejection, with or without clinical repercussion, was present in 44.4% of the patients.Conclusion:
Pediatric heart transplantation produces acceptable and feasible outcomes as definitive therapy for children with end-stage heart failure.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Observational study
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. bras. cir. cardiovasc
Journal subject:
Cardiology
/
General Surgery
Year:
2022
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
CardioPedBrasil - Hospital da Criança e Maternidade de São José do Rio Preto/BR
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