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A new biomarker in severe pneumonia associated with coronavirus disease 2019: hypoalbuminemia. A prospective study
Otal, Yavuz; Avcıoglu, Gamze; Haydar, Fadime Gullu.
  • Otal, Yavuz; Ankara City Hospital. Department of Emergency Medicine. Ankara. TR
  • Avcıoglu, Gamze; Karadeniz Ereğli State Hospital. Department of Medical Biochemistry. Zonguldak. TR
  • Haydar, Fadime Gullu; Ankara City Hospital. Department of General Surgery. Ankara. TR
São Paulo med. j ; 140(3): 378-383, May-June 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1377384
ABSTRACT
ABSTRACT

BACKGROUND:

Effective triage and early detection are very important for controlling and treating coronavirus disease 2019 (COVID-19). Thus, the relationships between hypoalbuminemia and other acute-phase reactants in such cases need to be evaluated.

OBJECTIVES:

To investigate the importance of albumin levels in cases of severe pneumonia due to COVID-19. DESIGN AND

SETTING:

Prospective study conducted in Ankara City Hospital (a stage 3 hospital), Turkey.

METHODS:

Data from 122 patients diagnosed with pneumonia due to COVID-19 who were admitted to this hospital were analyzed statistically in comparison with date from 60 healthy controls. Three groups were established healthy controls, intubated patients and non-intubated patients. Lung tomography scans from the patients were examined one-by-one. Real-time polymerase chain reaction (RT-PCR) test results were recorded.

RESULTS:

Albumin levels were statistically significantly lower in the intubated and non-intubated groups than in the control group, in comparing the three groups (P < 0.01). The other acute-phase reactants, i.e. neutrophil-to-lymphocyte ratio and C-reactive protein levels, were significantly higher in the intubated and non-intubated groups than in the control group (P < 0.05). Albumin levels were also significantly lower in the intubated group than in the non-intubated group (P = 0.02). No differences were detected with regard to other parameters (P > 0.05).

CONCLUSIONS:

Hypoalbuminemia may constitute a biomarker indicating the severity of pneumonia due to COVID-19.


Full text: Available Index: LILACS (Americas) Type of study: Observational study / Risk factors / Screening study Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2022 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ankara City Hospital/TR / Karadeniz Ere&#287;li State Hospital/TR

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Full text: Available Index: LILACS (Americas) Type of study: Observational study / Risk factors / Screening study Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2022 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ankara City Hospital/TR / Karadeniz Ere&#287;li State Hospital/TR