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Pentazocine versus tramadol-paracetamol combination as analgesia in labor: A randomized controlled trial
Oluwatunmobi Opadiran, Rachael; Isah, Dennis Anthony; Offiong, Richard; Dele Asudo, Felicia.
  • Oluwatunmobi Opadiran, Rachael; Department of Obstetrics and Gynaecology, University of Abuja, University of Abuja Teaching Hospital. Abuja. NG
  • Isah, Dennis Anthony; Department of Obstetrics and Gynaecology, University of Abuja, University of Abuja Teaching Hospital. Faculty of Clinical Sciences, University of Abuja, University of Abuja Teaching Hospital. Abuja. NG
  • Offiong, Richard; Department of Obstetrics and Gynaecology, University of Abuja, University of Abuja Teaching Hospital. Abuja. NG
  • Dele Asudo, Felicia; Department of Anaesthsia, University of Abuja, University of Abuja Teaching Hospital. Department of Anaesthsia, University of Abuja, University of Abuja Teaching Hospital. Abuja. NG
Annals of Medical Research and Practice ; 3(4): 1-9, 2022. tables, figures
Article in English | AIM | ID: biblio-1379212
ABSTRACT

Objectives:

Labor should be a satisfactory experience and effective pain management should be employed as recommended by the American Congress of Obstetricians and Gynaecologists. In developing countries, pain management in labor is still a big challenge and the search for the ultimate labor analgesia is still ongoing. The objectives of the study were to determine whether the synergistic analgesic effect of the combination of tramadol and paracetamol will produce analgesia comparable to pentazocine with a better side effect profile. Material and

Methods:

This was a randomized controlled, double-blinded trial of tramadol-paracetamol combination versus pentazocine as labor analgesia and was carried out at the University of Abuja Teaching Hospital, Abuja, between June 2018 and March 2019. A total of 218 eligible parturients recruited at term, were counseled on labor analgesia, its benefits, and the options made available to them and educated on the pain scoring system. Parturients were allocated into two groups using computer-generated numbers with the WINPEPI software. Group A was given tramadol-paracetamol combination, while Group B received pentazocine, both at standard doses. Hourly pain scores, APGAR scores, labor duration, patients' satisfaction, and side effects were collated. The level of significance was set at <0.05.

Results:

Tramadol-paracetamol was administered to 109 (50.9%) while pentazocine was administered to105 (49.1%) of the study participants. The mean age in the tramadol-paracetamol group was 29.6 ± 4.8 years, and in the pentazocine group, it was 28.8 ± 4.5 years. The difference in pain scores on the visual analog scale was statistically significant at the 3rd and 4th h (P = 0.02 and 0.004), but not significant in the 1st and 2nd h (P = 0.05 and 0.22) in the two groups. Overall, the average pain score in the tramadol-paracetamol group was significantly higher compared to the pentazocine group (5.27 ± 1.86 vs. 4.72 ± 1.54; P = 0.02). The 1st and 5th min APGAR scores (P = 0.44 and 0.67, respectively) of neonates in the tramadol-paracetamol and pentazocine groups were comparable. Nausea and drowsiness occurred more frequently in the pentazocine group at P-values of 0.047 and 0.0015, respectively. There was no statistically significant difference in the duration of labor between the tramadol-paracetamol and pentazocine groups. not statistically significant, a higher proportion of parturients in the pentazocine group was satisfied compared with the tramadol-paracetamol group (71.4% vs. 63.3%; P = 0.13).

Conclusion:

This study showed that intravenous pentazocine provides better pain relief in labor, but the tramadol-paracetamol combination has fewer side effects
Subject(s)


Full text: Available Index: AIM (Africa) Main subject: Pentazocine / Tramadol Type of study: Controlled clinical trial Limits: Female / Humans / Male Language: English Journal: Annals of Medical Research and Practice Year: 2022 Type: Article Institution/Affiliation country: Department of Anaesthsia, University of Abuja, University of Abuja Teaching Hospital/NG / Department of Obstetrics and Gynaecology, University of Abuja, University of Abuja Teaching Hospital/NG

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Full text: Available Index: AIM (Africa) Main subject: Pentazocine / Tramadol Type of study: Controlled clinical trial Limits: Female / Humans / Male Language: English Journal: Annals of Medical Research and Practice Year: 2022 Type: Article Institution/Affiliation country: Department of Anaesthsia, University of Abuja, University of Abuja Teaching Hospital/NG / Department of Obstetrics and Gynaecology, University of Abuja, University of Abuja Teaching Hospital/NG