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Early detection of acute renal lesions by serum cystatin C in children at hospital and university Centre of Brazzaville
Miguel, Landry Martial; Mabiala Wann, Tienelle Freiss; Dobhat-Doukakini, Choupette Ravelle; Njilo Tchatchouang, Didier Gesril; Lékana, Childérick; Bolanga, Ruphin Bertrand; Mokondjimobe, Etienne; Okoko, Annie Rachel; Moukassa, Donatien; Moyen, Georges; Abena, Ange Antoine.
  • Miguel, Landry Martial; Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University. Brazzaville. CG
  • Mabiala Wann, Tienelle Freiss; Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University. Brazzaville. CG
  • Dobhat-Doukakini, Choupette Ravelle; Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University. Brazzaville. CG
  • Njilo Tchatchouang, Didier Gesril; Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University. Brazzaville. CG
  • Lékana, Childérick; Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University. Brazzaville. CG
  • Bolanga, Ruphin Bertrand; 1Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University. Brazzaville. CG
  • Mokondjimobe, Etienne; Edith Bongo Ondimba general hospital. Oyo. CG
  • Okoko, Annie Rachel; Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University. Hospital and university center of Brazzaville. Brazzaville. CG
  • Moukassa, Donatien; Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University. Edith Bongo Ondimba general hospital, Oyo, Republic of Congo. Brazzaville. CG
  • Moyen, Georges; Hospital and university center of Brazzaville. Brazzaville. CG
  • Abena, Ange Antoine; Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University. Dénis Sassou N'Guesso University, Kintélé, Republic of Congo. Brazzaville. CG
Afr. j. health sci ; 35(3): 332-342, 2022. figures, tables
Article in English | AIM | ID: biblio-1380186
ABSTRACT
Acute Kidney Injury (AKI) is considered one of the main public health problems. The effective management of these alterations is based on the early detection of renal lesions. The objective of this study was to evaluate the contribution of the Cystatin C (CysC) assay in the early diagnosis of acute kidney injury (AKI) in children hospitalized in pediatric intensive care units in Brazzaville. MATERIALS AND METHODS Sixty children at high risk of developing AKI were included. Consent form signed was obtained from parents, socio-demographic data, weight and height of children recorded. Creatinine (Cr), CysC and urea were assayed in serum 24 hours after admission. Glomerular filtration clearance was estimated using serum creatinine and CysC. Glomerular filtration rate (GFR) was calculated from CysC and Cr. The diagnostic accuracy was determined by comparing the results of CysC to those of Cr (considered as a reference biomarker). RESULTS The median age was 5 years (with extremes ranging from 1 month to 17 years). Cr, CysC, urea, and GFR/Cr (mean ± standard deviation [range]) were 0.94±1.17 (0.2­ 1.4 mg/dl), 0.14 ± 0.062 (0.053-0.095 mg/l), 46.65±47.75 (15.0­45.0 mg/dl), 81.85±31.90 (≥190 ml/min per 1.73 m2 , respectively. The level of CysC in patients with ARL was significantly higher than that of children with normal renal function (p<0.001). Our results show that the performance of serum CysC in detecting AKI early was superior to that of serum Cr in children hospitalized in pediatric intensive care units in Brazzaville
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Full text: Available Index: AIM (Africa) Main subject: Creatinine / Early Diagnosis / Cystatin C / Acute Kidney Injury Type of study: Diagnostic study / Observational study / Screening study Limits: Adolescent / Child / Child, preschool / Humans Language: English Journal: Afr. j. health sci Year: 2022 Type: Article Institution/Affiliation country: 1Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University/CG / Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University/CG / Edith Bongo Ondimba general hospital/CG / Hospital and university center of Brazzaville/CG

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Full text: Available Index: AIM (Africa) Main subject: Creatinine / Early Diagnosis / Cystatin C / Acute Kidney Injury Type of study: Diagnostic study / Observational study / Screening study Limits: Adolescent / Child / Child, preschool / Humans Language: English Journal: Afr. j. health sci Year: 2022 Type: Article Institution/Affiliation country: 1Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University/CG / Clinical and molecular biochemistry unit, Faculty of Health Sciences, Marien Ngouabi University/CG / Edith Bongo Ondimba general hospital/CG / Hospital and university center of Brazzaville/CG