Case for diagnosis. Radiotherapy-induced pemphigus vegetans
An. bras. dermatol
;
97(3): 376-378, 2022. graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1383563
ABSTRACT
Abstract A 73-year-old male patient developed a poorly differentiated squamous cell carcinoma in the anal canal nine months ago. He was treated with two cycles of 5-fluorouracil and cisplatin and concomitant radiotherapy (6 MeV linear photon accelerator, total dose of 54 Gy), with complete remission. Since forty-five days he presentes a painful perianal and intergluteal erosion with circinate pustular borders. Light microscopy showed pseudoepitheliomatous hyperplasia of the epidermis with microabscesses of inflammatory cells (neutrophils and eosinophils) and acantholytic keratinocytes . Indirect immunofluorescence was positive for IgG, with an intercellular pattern, 180 titer. The diagnosis of radiotherapy-induced pemphigus vegetans was established and there was significant regression with oral prednisone (40 mg) and topical betamethasone.
Full text:
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Index:
LILACS (Americas)
Type of study:
Diagnostic study
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2022
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Santa Casa de Misericórdia de Porto Alegre/BR
/
Universidade Católica de Pelotas/BR
/
Universidade Federal de Pelotas/BR
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