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Case for diagnosis. Radiotherapy-induced pemphigus vegetans
Almeida Jr, Hiram Larangeira de; Almeida, Antônia Larangeira de; Martinez, Pedro Henrique Evangelista; Boff, Ana Letícia.
  • Almeida Jr, Hiram Larangeira de; Universidade Católica de Pelotas. departamento de dermatologia. Pelotas. BR
  • Almeida, Antônia Larangeira de; Universidade Federal de Pelotas. Liga de Dermatologia. Pelotas. BR
  • Martinez, Pedro Henrique Evangelista; Universidade Federal de Pelotas. Liga de Dermatologia. Pelotas. BR
  • Boff, Ana Letícia; Santa Casa de Misericórdia de Porto Alegre. Laboratório Dermapat. Porto Alegre. BR
An. bras. dermatol ; 97(3): 376-378, 2022. graf
Article in English | LILACS-Express | LILACS | ID: biblio-1383563
ABSTRACT
Abstract A 73-year-old male patient developed a poorly differentiated squamous cell carcinoma in the anal canal nine months ago. He was treated with two cycles of 5-fluorouracil and cisplatin and concomitant radiotherapy (6 MeV linear photon accelerator, total dose of 54 Gy), with complete remission. Since forty-five days he presentes a painful perianal and intergluteal erosion with circinate pustular borders. Light microscopy showed pseudoepitheliomatous hyperplasia of the epidermis with microabscesses of inflammatory cells (neutrophils and eosinophils) and acantholytic keratinocytes . Indirect immunofluorescence was positive for IgG, with an intercellular pattern, 180 titer. The diagnosis of radiotherapy-induced pemphigus vegetans was established and there was significant regression with oral prednisone (40 mg) and topical betamethasone.


Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Santa Casa de Misericórdia de Porto Alegre/BR / Universidade Católica de Pelotas/BR / Universidade Federal de Pelotas/BR

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Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Santa Casa de Misericórdia de Porto Alegre/BR / Universidade Católica de Pelotas/BR / Universidade Federal de Pelotas/BR