Icatibant use in Brazilian patients with hereditary angioedema (HAE) type 1 or 2 and HAE with normal C1-INH levels: findings from the Icatibant Outcome Survey Registry Study
An. bras. dermatol
;
97(4): 448-457, July-Aug. 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1383602
ABSTRACT
Abstract Background:
Hereditary angioedema can be caused by C1-Inhibitor (C1-INH) deficiency and/or dysfunction (HAE-1/2) or can occur in patients with normal C1-INH (HAE nC1-INH).Methods:
The Icatibant Outcome Survey (IOS; NCT01034969) registry monitors the safety and effectiveness of icatibant for treating acute angioedema.Objective:
Present findings from Brazilian patients with HAE-1/2 and HAE nC1-INH participating in IOS.Results:
42 patients were enrolled (HAE-1/2, n = 26; HAE nC1-INH, n = 16). Median age at symptom onset was significantly lower with HAE-1/2 vs. HAE nC1-INH (10.0 vs. 16.5y, respectively; p = 0.0105), whereas median age at diagnosis (31.1 vs. 40.9y; p = 0.1276) and the median time between symptom onset and diagnosis (15.0 vs. 23.8y; p = 0.6680) were numerically lower vs. HAEnC1-INH, respectively. One icatibant dose was used for > 95% of HAE attacks. Median (range) time-to-event outcomes were shorter for patients with HAE nC1-INH vs. HAE-1/2, including time Studylimitations:
This was an observational study without a treatment comparator and that relied on patient recall.Conclusions:
Findings demonstrate effectiveness and tolerability of icatibant in Brazilian HAE patients.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Diagnostic study
/
Observational study
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2022
Type:
Article
/
Project document
Affiliation country:
Brazil
/
Switzerland
Institution/Affiliation country:
Centro Universitario Saúde ABC/BR
/
Takeda Distribuidora Ltda/BR
/
Takeda Pharmaceuticals International AG/CH
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