Naringin is a promising natural compound for therapy of iron-overload disorders
Braz. J. Pharm. Sci. (Online)
;
58: e19409, 2022. graf
Article
in English
| LILACS
| ID: biblio-1383963
ABSTRACT
Abstract Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for treatment of excessive iron-related diseases. 35 mice were classified into five groups of 7 and subjected to iron dextran administration to induce the iron-overload condition. Iron-overloaded mice were then treated with normal saline (as control), naringin or DFO Morphology changes, and iron deposition in liver tissues were studied using H&E and Perl's staining. The results revealed that naringin is more potent than DFO in removing excessive iron ions deposited in liver tissues, indicating that naringin is a promising natural compound for therapy of iron overload disorders
Full text:
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Index:
LILACS (Americas)
Main subject:
Iron Overload
/
Flavanones
Limits:
Animals
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2022
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Golestan University of Medical Sciences/IR
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