Investigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes
Braz. J. Pharm. Sci. (Online)
;
58: e19668, 2022. tab, graf
Article
in English
| LILACS
| ID: biblio-1383976
ABSTRACT
Abstract Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to promote the growth, proliferation, and migration of endothelial and keratinocyte cells. Chitosan has been widely used as a biopolymer in wound-healing studies. The aim of this study was to investigate the in vitro proliferative effects of chitosan/pGM-CSF complexes as well as the therapeutic role of the complexes in an in vivo rat wound model. The effect of complexes on cell proliferation and migration was examined. Wounds were made in Wistar-albino rats, and examined histopathologically. The cell proliferation and migration were increased weight ratio- and time-dependently in HaCaT and NIH-3T3 cell lines. Wound healing was significantly accelerated in rats treated with the complexes. These results showed that the delivery of pGM-CSF using chitosan complexes could play an accelerating role in the cell proliferation, migration, and wound-healing process.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Therapeutics
/
Wound Healing
/
Wounds and Injuries
/
Therapeutic Uses
/
Chitosan
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2022
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Inönü University/TR
/
Inönü University/TR
/
Izmir Atatürk Education and Research Hospital/TR
/
Marmara University/TR
/
Medipol University/TR
/
University of Health Sciences/TR
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