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Global endothelial function assessment using pulse wave analysis in hypercholesterolemia
Ibrahim, Nik Nor Izah Nik; Rahman, Razlina Abdul; Azlan, Maryam; Rasool, Aida Hanum Ghulam.
  • Ibrahim, Nik Nor Izah Nik; University Sains Malaysia. School of Medical Sciences. Department of Pharmacology. Kubang Kerian. MY
  • Rahman, Razlina Abdul; University Sains Malaysia. School of Medical Sciences. Department of Family Medicine. Kubang Kerian. MY
  • Azlan, Maryam; University Sains Malaysia. School of Health Sciences. Kubang Kerian. MY
  • Rasool, Aida Hanum Ghulam; University Sains Malaysia. School of Medical Sciences. Department of Pharmacology. Kubang Kerian. MY
Braz. J. Pharm. Sci. (Online) ; 58: e191010, 2022. tab
Article in English | LILACS | ID: biblio-1384021
ABSTRACT
To compare global endothelial function assessed by pulse wave analysis (PWA) using the ratio of endothelium dependent vasodilatation (EDV) to endothelium independent vasodilatation (EIV) in patients with hypercholesterolemia and controls. 92 subjects [46 hypercholesterolemics, 46 controls] were studied at standardized conditions. Baseline augmentation index (AIx) was assessed followed by the administration of 0.5 mg sublingual nitroglycerine, an endothelium independent vasodilator. AIx was assessed and the maximum change in AIx after nitroglycerine was recorded as EIV. After a washout period of 30 minutes, 400 µg of inhaled salbutamol, an endothelium dependent vasodilator was administered. AIx was assessed again and the maximum change in AIx after salbutamol was recorded as EDV. Global endothelial function was calculated as EDVEIV ratio. EDV and EIV in patients with hypercholesterolemia compared to controls were 2.97 ± 3.95 and 6.65 ± 3.80 (p<0.001); and 13.41 ± 4.57 and 15.88 ± 4.78 (p=0.01) respectively. EDVEIV ratio was significantly reduced in patients with hypercholesterolemia compared to controls; 0.21 ± 0.38 and 0.44 ± 0.24 (p<0.001) respectively. EDVEIV ratio was significantly reduced in patients with hypercholesterolemia compared to controls. PWA is a potential clinical tool to assess global endothelial function in patients with hypercholesterole
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Full text: Available Index: LILACS (Americas) Main subject: Endothelium / Pulse Wave Analysis / Hypercholesterolemia Limits: Adult / Female / Humans / Male Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Malaysia Institution/Affiliation country: University Sains Malaysia/MY

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Full text: Available Index: LILACS (Americas) Main subject: Endothelium / Pulse Wave Analysis / Hypercholesterolemia Limits: Adult / Female / Humans / Male Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Malaysia Institution/Affiliation country: University Sains Malaysia/MY