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Identification and characterization of nontuberculous mycobacteria isolated from suspected pulmonary tuberculosis patients in eastern china from 2009 to 2019 using an identification array system
Zhu, Yelei; Hua, Wenya; Liu, Zhengwei; Zhang, Mingwu; Wang, Xiaomeng; Wu, Beibei; Wang, Zhen; Chen, Jiazhen.
  • Zhu, Yelei; Zhejiang Provincial Center for Disease Control and Prevention. Hangzhou. CN
  • Hua, Wenya; National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University. Department of Infectious Diseases. Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response. CN
  • Liu, Zhengwei; Zhejiang Provincial Center for Disease Control and Prevention. Hangzhou. CN
  • Zhang, Mingwu; Zhejiang Provincial Center for Disease Control and Prevention. Hangzhou. CN
  • Wang, Xiaomeng; Zhejiang Provincial Center for Disease Control and Prevention. Hangzhou. CN
  • Wu, Beibei; Zhejiang Provincial Center for Disease Control and Prevention. Hangzhou. CN
  • Wang, Zhen; Zhejiang Provincial Center for Disease Control and Prevention. Hangzhou. CN
  • Chen, Jiazhen; National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University. Department of Infectious Diseases. Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response. CN
Braz. j. infect. dis ; 26(2): 102346, 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1384122
ABSTRACT
Abstract Objective Nontuberculous mycobacteria (NTM) species are increasingly being isolated and have become a key factor affecting public health by causing pulmonary diseases. Most NTM species do not respond to conventional tuberculosis (TB) drugs. This study aimed to identify NTM isolated from suspected pulmonary TB patients from the Zhejiang province and analyze their distribution in the region. Methods A total of 1,113 NTM isolates from patients suspected to be suffering from acid-fast bacilli-positive tuberculosis were identified at the species level, using the CapitalBio Mycobacterium identification array and polymerase chain reaction amplification and sequencing of 16S-23S gene internal transcribed spacer (ITS), 16S rRNA, and hsp65. Results Of the 23,138 isolates, we identified 1,102 NTM (4.8%), mainly including Mycobacterium intracellulare (54.81%, 604/1,102), M. chelonae-M. abscessus (16.52%, 182/1,102), M. avium (13.16%, 145/1,102), M. kansasii (8.17%, 90/1,102), and M. gordonae (3.27%, 36/1,102). Conclusion The distribution of NTM species observed in patients with suspected pulmonary tuberculosis provides guidance for the diagnosis and treatment of NTM pulmonary diseases.


Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study / Practice guideline / Prognostic study Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2022 Type: Article Affiliation country: China Institution/Affiliation country: National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University/CN / Zhejiang Provincial Center for Disease Control and Prevention/CN

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Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study / Practice guideline / Prognostic study Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2022 Type: Article Affiliation country: China Institution/Affiliation country: National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University/CN / Zhejiang Provincial Center for Disease Control and Prevention/CN