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Whole genome characterization, and geographical distribution of M. tuberculosis in central region of Veracruz, Mexico
Fernández-Morales, Esdras Antonio; Bermudez, Gustavo; Montero, Hilda; Luzania-Valerio, Manuel; Zenteno-Cuevas, Roberto.
  • Fernández-Morales, Esdras Antonio; University of Veracruz. Health Sciences Institute. MX
  • Bermudez, Gustavo; University of Veracruz. Health Sciences Institute. MX
  • Montero, Hilda; University of Veracruz. Public Health Institute. MX
  • Luzania-Valerio, Manuel; University of Veracruz. Public Health Institute. MX
  • Zenteno-Cuevas, Roberto; University of Veracruz. Public Health Institute. MX
Braz. j. infect. dis ; 26(3): 102357, 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1384129
ABSTRACT
ABSTRACT The purpose of this work was to perform by Whole Genomic Sequencing (WGS) a characterization of tuberculosis isolates circulating in the central region of Veracruz, Mexico, and to determine its geographical distribution. The genome of 25 clinical isolates of tuberculosis patients, recovered from central zone of Veracruz, Mexico, were sequenced and the information obtained was used to characterize lineage, prediction of drug resistance, identification of clonal complexes, and finally correlated with the geolocalization data. Isolates analyzed were included into seven L4 sublineages, most frequent was X3; X1 (4.1.1.3) in 35%. rpoBSer450Leu polymorphism was the most frequently found variant. Sublineage Haarlem (4.1.2) had the widest distribution, found in five municipalities. Of the of two clonal complexes found, the most abundant included eight isolates, with X3/X1 lineage, placed in two municipalities. Combination of WGS and geographic information system was very useful for the identification of sublineages, clonal complexes, and their geographical dispersion with important implications in the epidemiological surveillance and clinical control of TB.


Full text: Available Index: LILACS (Americas) Country/Region as subject: Mexico Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2022 Type: Article Affiliation country: Mexico Institution/Affiliation country: University of Veracruz/MX

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Full text: Available Index: LILACS (Americas) Country/Region as subject: Mexico Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2022 Type: Article Affiliation country: Mexico Institution/Affiliation country: University of Veracruz/MX