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Lung function six months after severe COVID-19: Does time, in fact, heal all wounds?
Bretas, Daniel Cruz; Leite, Arnaldo Santos; Mancuzo, Eliane Viana; Prata, Tarciane Aline; Andrade, Bruno Horta; Oliveira, Jacqueline das Graças Ferreira; Batista, Aline Priscila; Machado-Coelho, George Luiz Lins; Augusto, Valéria Maria; Marinho, Carolina Coimbra.
  • Bretas, Daniel Cruz; Universidade Federal de Minas Gerais (UFMG). Belo Horizonte. BR
  • Leite, Arnaldo Santos; Universidade Federal de Minas Gerais (UFMG). Belo Horizonte. BR
  • Mancuzo, Eliane Viana; Universidade Federal de Minas Gerais (UFMG). Belo Horizonte. BR
  • Prata, Tarciane Aline; Universidade Federal de Minas Gerais (UFMG). Belo Horizonte. BR
  • Andrade, Bruno Horta; Universidade Federal de Minas Gerais (UFMG). Belo Horizonte. BR
  • Oliveira, Jacqueline das Graças Ferreira; Fundação Hospitalar de Minas Gerais (FHEMIG). Hospital Eduardo de Menezes. Belo Horizonte. BR
  • Batista, Aline Priscila; Universidade Federal de Ouro Preto (UFOP). Ouro Preto. BR
  • Machado-Coelho, George Luiz Lins; Universidade Federal de Ouro Preto (UFOP). Ouro Preto. BR
  • Augusto, Valéria Maria; Universidade Federal de Minas Gerais (UFMG). Belo Horizonte. BR
  • Marinho, Carolina Coimbra; Universidade Federal de Minas Gerais (UFMG). Belo Horizonte. BR
Braz. j. infect. dis ; 26(3): 102352, 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1384134
ABSTRACT
ABSTRACT

Background:

COVID-19 has been associated with persistent symptoms and functional changes, especially in those surviving severe disease.

Methods:

We conducted a prospective multicenter study in patients with severe COVID-19 to determine respiratory sequelae. Patients were stratified into two groups ward admission (WA) and intensive care unit (ICU) admission. In each follow-up visit, the patients where inquired about cough and dyspnea, and performed spirometry, lung volumes, carbon monoxide diffusion capacity (DLCO), 6-minute walk test (6MWT), and respiratory muscle strength (MIP and MEP). Results of pulmonary function tests at 45 days and 6 months after hospital admission were compared using paired analysis.

Results:

211 patients were included, 112 in WA and 99 in ICU. Dyspnea persisted in 64.7% in the WA and 66.7% in the ICU group after 6 months. Lung function measures showed significant improvement between 45 days and 6 months, both in WA and ICU groups in VC, FVC, FEV1, total lung capacity, and 6MW distance measures. The improvement in the proportions of the altered functional parameters was significant in the ICU group for VC (44.2% 45 d; 20.8% 6 m; p = 0,014), FVC (47.6% 45 d; 28% 6 m; p = 0,003), FEV1 (45.1% 45 d; 28% 6 m; p = 0,044), DLCO (33.8% 45 d; 7.7% 6 m; p < 0,0001).

Conclusion:

Six months follow-up of patients with the severe forms of COVID-19 showed significant improvement in the lung function measures compared to 45 days post hospital discharge. The difference was more evident in those requiring ICU admission.


Full text: Available Index: LILACS (Americas) Type of study: Controlled clinical trial Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Hospitalar de Minas Gerais (FHEMIG)/BR / Universidade Federal de Minas Gerais (UFMG)/BR / Universidade Federal de Ouro Preto (UFOP)/BR

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Full text: Available Index: LILACS (Americas) Type of study: Controlled clinical trial Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Hospitalar de Minas Gerais (FHEMIG)/BR / Universidade Federal de Minas Gerais (UFMG)/BR / Universidade Federal de Ouro Preto (UFOP)/BR