Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men
Braz. j. med. biol. res
;
55: e12110, 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1384141
ABSTRACT
In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia 4.16±0.85 vs normoxia 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia 8.40±3.84 vs normoxia 5.73±2.15 pg/mL, P=0.04) increased, whereas matrix metalloproteinase (MMP-9) activity (hyperoxia 0.53±0.11 vs normoxia 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.
Full text:
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Index:
LILACS (Americas)
Type of study:
Prognostic study
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2022
Type:
Article
Affiliation country:
Brazil
/
Denmark
Institution/Affiliation country:
Instituto Nacional de Qualidade e Tecnologia Metrológica/BR
/
Universidade Federal Fluminense/BR
/
Universidade de Brasília/BR
/
University of Copenhagen/DK
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