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Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19
Mendonça, Michelle Mendanha; Cruz, Kellen Rosa da; Pinheiro, Denise da Silva; Moraes, Gean Carlos Alves; Ferreira, Patricia Maria; Ferreira Neto, Marcos Luiz; Silva, Eduardo Sérgio da; Gonçalves, Reggiani Vilela; Pedrino, Gustavo Rodrigues; Fajemiroye, James O; Xavier, Carlos Henrique.
  • Mendonça, Michelle Mendanha; Universidade Federal de Goiás - UFG. Instituto de Ciências Biológicas. Goiânia. BR
  • Cruz, Kellen Rosa da; Universidade Federal de Goiás - UFG. Instituto de Ciências Biológicas. Goiânia. BR
  • Pinheiro, Denise da Silva; Universidade Federal de Goiás - UFG. Instituto de Ciências Biológicas. Goiânia. BR
  • Moraes, Gean Carlos Alves; Universidade Federal de Goiás - UFG. Instituto de Ciências Biológicas. Goiânia. BR
  • Ferreira, Patricia Maria; Universidade Federal de Goiás - UFG. Instituto de Ciências Biológicas. Goiânia. BR
  • Ferreira Neto, Marcos Luiz; Universidade Federal de Uberlândia - UFU. Instituto de Ciências Biomédicas - ICBIM. Uberlândia. BR
  • Silva, Eduardo Sérgio da; Universidade Federal de São João Del-Rei - UFSJ. Divinópolis. BR
  • Gonçalves, Reggiani Vilela; Universidade Federal de Viçosa - UFV. Viçosa. BR
  • Pedrino, Gustavo Rodrigues; Universidade Federal de Goiás - UFG. Instituto de Ciências Biológicas. Goiânia. BR
  • Fajemiroye, James O; Universidade Federal de Goiás - UFG. Instituto de Ciências Biológicas. Goiânia. BR
  • Xavier, Carlos Henrique; Universidade Federal de Goiás - UFG. Instituto de Ciências Biológicas. Goiânia. BR
Hematol., Transfus. Cell Ther. (Impr.) ; 44(2): 235-245, Apr.-June 2022. tab, graf
Article in English | LILACS | ID: biblio-1385065
ABSTRACT
Abstract Introduction The evolving COVID-19 pandemic became a hallmark in human history, not only by changing lifestyles, but also by enriching scientific knowledge on viral infection and its consequences. Objective Although the management of cardiorespiratory changes is pivotal to a favorable prognosis during severe clinical findings, dysregulation of other systems caused by SARS-CoV-2 infection may imbalance erythrocyte dynamics, such as a bidirectional positive feedback loop pathophysiology. Method and Results Recent evidence shows that SARS-CoV-2 is capable of affecting the genetics and dynamics of erythrocytes and this coexists with a non-homeostatic function of cardiovascular, respiratory and renal systems during COVID-19. In hypothesis, SARS-CoV-2-induced systematical alterations of erythrocytes dynamics would constitute a setpoint for COVID-19-related multiple organ failure syndrome and death. Conclusion The present review covers the most frequent erythrocyte-related non-homeostatic findings during COVID-19 capable of providing mechanistic clues of SARS-CoV-2-induced infection and inspiring therapeutic-oriented scientific evidence.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Erythrocytes / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Language: English Journal: Hematol., Transfus. Cell Ther. (Impr.) Journal subject: Hematologia / TransfusÆo de Sangue Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Goiás - UFG/BR / Universidade Federal de São João Del-Rei - UFSJ/BR / Universidade Federal de Uberlândia - UFU/BR / Universidade Federal de Viçosa - UFV/BR

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Full text: Available Index: LILACS (Americas) Main subject: Erythrocytes / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Language: English Journal: Hematol., Transfus. Cell Ther. (Impr.) Journal subject: Hematologia / TransfusÆo de Sangue Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Goiás - UFG/BR / Universidade Federal de São João Del-Rei - UFSJ/BR / Universidade Federal de Uberlândia - UFU/BR / Universidade Federal de Viçosa - UFV/BR