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Small bronchiolar histopathological changes related to prolonged diabetes / Pequeños cambios histopatológicos bronquiolares relacionados con la diabetes prolongada
Chookliang, Amornrat; Lanlua, Passara; Niyomchan, Apichaya; Sricharoenvej, Sirinush.
  • Chookliang, Amornrat; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Anatomy. Bangkok. TH
  • Lanlua, Passara; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Anatomy. Bangkok. TH
  • Niyomchan, Apichaya; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Anatomy. Bangkok. TH
  • Sricharoenvej, Sirinush; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Anatomy. Bangkok. TH
Int. j. morphol ; 39(2): 371-377, abr. 2021. ilus
Article in English | LILACS | ID: biblio-1385372
ABSTRACT

SUMMARY:

Diabetes mellitus increases the risk of developing chronic obstructive pulmonary disease (COPD). The small bronchiole is a prominent site of airflow obstruction that causes increased airway resistance in patients with the COPD. Therefore, the histological and ultrastructural changes in small bronchioles in streptozotocin (STZ)-induced chronic diabetes were determined. Twenty-four weeks after STZ induction, rats were sacrificed, and the right and left lungs were collected for examination by light and electron microscopy. The alterations to the small bronchioles were the same in both lungs of these diabetic rats. The bronchiolar epithelial cells, both ciliated and secretory club cells, showed pyknotic nuclei and damaged cytoplasmic organelles. Increased thickening of the bronchiolar wall occurred in diabetic rats due to smooth muscle layer thickening, inflammatory cell infiltration, and increased numbers of myofibroblasts with collagen deposition.These results indicated that chronic diabetes caused extreme damage to small bronchioles, which may lead to chronic small airway obstruction and ultimately increase the likelihood of COPD progression. This basic knowledge provides a better understanding of the progression of pathogenesis in the small airways of patients with prolonged diabetes.
RESUMEN
RESUMEN La diabetes mellitus aumenta el riesgo de desarrollar enfermedad pulmonar obstructiva crónica (EPOC). El bronquiolo es un sitio prominente de obstrucción del flujo de aire que causa una mayor resistencia de las vías respiratorias en pacientes con EPOC. Por lo tanto, se determinaron los cambios histológicos y ultraestructurales en los bronquiolos en la diabetes crónica inducida por estreptozotocina (STZ). 24 semanas después de la inducción de STZ, se sacrificaron las ratas y se analizaron los pulmones derecho e izquierdo por microscopía óptica y electrónica. Las alteraciones de los pequeños bronquiolos fueron las mismas en ambos pulmones de estas ratas diabéticas. Las células epiteliales bronquiolares, tanto ciliadas como secretoras, mostraban núcleos picnóticos y orgánelos citoplasmáticos dañados. Se produjo un aumento del engrosamiento de la pared bronquiolar en ratas diabéticas debido al engrosamiento de la capa de músculo liso, infiltración de células inflamatorias y un mayor número de miofibroblastos con colágeno. Estos resultados indicaron que la diabetes crónica causaba daño extremo a los pequeños bronquiolos, lo que puede conducir a una obstrucción crónica de las vías respiratorias pequeñas y además aumentar la probabilidad de progresión de la EPOC. Esta información proporcionará un mejor conocimiento de la patogénesis en las vías respiratorias pequeñas de los pacientes con diabetes prolongada.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bronchi / Diabetes Mellitus, Experimental Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2021 Type: Article Affiliation country: Thailand Institution/Affiliation country: Mahidol University/TH

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Full text: Available Index: LILACS (Americas) Main subject: Bronchi / Diabetes Mellitus, Experimental Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2021 Type: Article Affiliation country: Thailand Institution/Affiliation country: Mahidol University/TH