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Could Aspirin Treatment Modify the Assessment of the Uterine Arteries? / O tratamento com aspirina pode modificar a avaliação das artérias uterinas?
Vallejo, Gabriela Marisol; Uriel, Montserrat; Porras-Ramírez, Alexandra; Romero, Ximena Carolina.
  • Vallejo, Gabriela Marisol; Universidad El Bosque. El Bosque Research Group of Maternal Fetal, Medicine and Gynecology. Ecodiagnóstico El Bosque SAS. Bogotá. CO
  • Uriel, Montserrat; Universidad El Bosque. El Bosque Research Group of Maternal Fetal, Medicine and Gynecology. Ecodiagnóstico El Bosque SAS. Bogotá. CO
  • Porras-Ramírez, Alexandra; El Bosque University. Research Group Community Medicine and Collective Health. Los Cobos Medical Center. Bogotá. CO
  • Romero, Ximena Carolina; Universidad El Bosque. El Bosque Research Group of Maternal Fetal, Medicine and Gynecology. Ecodiagnóstico El Bosque SAS. Bogotá. CO
Rev. bras. ginecol. obstet ; 44(3): 231-237, Mar. 2022. tab, graf
Article in English | LILACS | ID: biblio-1387874
ABSTRACT
Abstract Objective To analyze whether acetylsalicylic (ASA) intake modifies the mean uterine arteries pulsatility index (UtA-PI) at the 2nd or 3rd trimester in a cohort of pregnant women with abnormal mean UtA-PI at between 11 and 14 weeks of gestation. Methods This is a retrospective cohort study. Singleton pregnancies with abnormal mean UtA-PI at between 11 and 14 weeks of gestation were studied. The participants were divided into 3 groups 1) If the participant did not take ASA during pregnancy; 2) If the participant took ASA before 14 weeks of gestation; and 3) If the participant took ASA after 14 weeks of gestation. The mean UtA-PI was evaluated at the 2nd and 3rd trimesters, and it was considered to improve when it decreased below the 95th percentile. The prevalence ratio (PR) and the number needed to treat (NNT) werecalculated. Results A total of 72 participants with a mean UtA-PI>95th percentile at the 1st trimester of gestation were evaluated. Out of the 18 participants who took ASA, 8 participants started it before 14 weeks of gestation and 10 after. A total of 33.3% of these participants had improved the mean UtA-PI at the 2nd and 3rd trimesters of gestation, although it was not statistically significant (p=0.154). The prevalence ratio was 0.95 (95% confidence interval [CI] 0.31-1.89), but between the 1st and 2nd trimesters of gestation, the PR was 0.92 (95%CI 0.21-0.99) and it was statistically significant. Conclusion The present work demonstrates a modification of the mean UtA-PI in participants who took ASA compared with those who did not. It is important to check if ASA can modify the normal limits of uterine arteries because this could have an impact on surveillance.
RESUMO
Resumo Objetivo Analisar se a ingestão de acetilsalicílico (ASA) modifica o índice médio de pulsatilidade das artérias uterinas (UtA-PI) no 2° ou 3° trimestre em uma coorte de gestantes com média anormal de UtA-PI entre 11 e 14 semanas. Métodos Este é um estudo de coorte retrospectivo. Gravidezes únicas com média anormal de UtA-PI entre 11 e 14 semanas foram estudadas. As participantes foram divididas em 3 grupos 1) Se a participante não tomou ASA durante a gravidez, 2) Se a participante tomou AAS antes das 14 semanas e 3) Se a participante tomou ASA após 14 semanas. A média do UtA-PI foi avaliada nos 2° e 3° trimestres e considerou-se que melhorava quando diminuía<95° percentil. Foram calculados a razão de prevalência (RP) e o número necessário para tratar (NNT). Resultados Foram avaliadas 72 participantes com média de UtA-PI>95° percentil no 1° trimestre de gravidez. Das 18 participantes que tomaram ASA, 8 participantes começaram antes de 14 semanas e 10 depois. Um total de 33,3% desses participantes melhoraram a média de UtA-PI nos 2° e 3° trimestres, embora não tenha sido estatisticamente significante (p=0,154). A razão de prevalência foi de 0,95 (intervalo de confiança [IC95%] 0,31-1,89), mas entre os 1° e o 2° trimestres, a RP foi de 0,92 (IC95% 0,21-0,99) e foi estatisticamente significativa. Conclusão O presente trabalho demonstra uma modificação da média de UtA-PI em participantes que faziam uso de ASA em comparação com aqueles que não faziam. É importante verificar se o ASA pode modificar os limites normais das artérias uterinas porque isso pode ter um impacto na vigilância.
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Full text: Available Index: LILACS (Americas) Main subject: Pre-Eclampsia / Aspirin / Ultrasonography / Ultrasonography, Doppler, Color / Uterine Artery Type of study: Observational study / Risk factors Limits: Female / Humans / Pregnancy Language: English Journal: Rev. bras. ginecol. obstet Journal subject: Gynecology / Obstetrics Year: 2022 Type: Article Affiliation country: Colombia Institution/Affiliation country: El Bosque University/CO / Universidad El Bosque/CO

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Full text: Available Index: LILACS (Americas) Main subject: Pre-Eclampsia / Aspirin / Ultrasonography / Ultrasonography, Doppler, Color / Uterine Artery Type of study: Observational study / Risk factors Limits: Female / Humans / Pregnancy Language: English Journal: Rev. bras. ginecol. obstet Journal subject: Gynecology / Obstetrics Year: 2022 Type: Article Affiliation country: Colombia Institution/Affiliation country: El Bosque University/CO / Universidad El Bosque/CO