Taxane-induced scleroderma: report of two cases / Esclerodermia inducida por taxanos: informe de dos casos
Rev. méd. Chile
;
149(5): 807-809, mayo 2021. ilus
Article
in English
| LILACS
| ID: biblio-1389503
ABSTRACT
ABSTRACT Taxanes are a class of chemotherapeutic agents with common associated dermatologic adverse events, such as skin hyperpigmentation, hand-foot skin syndrome, paronychia and onycholysis. Taxane-induced scleroderma is rare. Few cases with skin findings resembling systemic sclerosis, have been reported after the administration of these agents. We report two cases with stage IV breast cancer, aged 66 and 71 years, who developed sclerodermic skin lesions in their extremities after starting treatment with placlitaxel and nabplaclitaxel respectively.
RESUMEN
Los taxanos son agentes quimioterapéuticos cuyo uso se asocia a problemas dermatológicos tales como hiperpigmentación, síndrome manos-pies, paroniquia y onicolisis. La esclerodermia inducida por taxanos es rara, con pocos casos informados en la literatura. Informamos los casos de dos pacientes con cáncer de mama en estado IV, de 66 y 71 años, que desarrollaron lesiones esclerodérmicas en las extremidades después de ser tratadas con placlitaxel y nabplaclitaxel, respectivamente.
Full text:
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Index:
LILACS (Americas)
Main subject:
Scleroderma, Systemic
/
Breast Neoplasms
/
Antineoplastic Agents
Limits:
Female
/
Humans
Language:
English
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2021
Type:
Article
Affiliation country:
Brazil
/
Chile
Institution/Affiliation country:
Pontificia Universidad Católica de Chile/CL
/
University of São Paulo Medical School/BR
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