Evaluación de la actividad cerebro-cerebelar cruzada para determinar la lateralidad del lenguaje en pacientes con tumores cerebrales / Evaluation of the crossed cerebro-cerebellar activation to determine language lateralization in patients with brain tumors
Rev. méd. Chile
;
149(5): 689-697, mayo 2021. tab, ilus
Article
in Spanish
| LILACS
| ID: biblio-1389520
ABSTRACT
Background:
The crossed cerebro-cerebellar (CCC) activation facilitates the diagnosis of cortical language lateralization, but needs to be explored with language tasks suitable for patients with different age ranges, educational attainment and eventual presence of language deficits.Aim:
To determine the effect of demographic variables in the performance of three language tasks in healthy volunteers and to determine the CCC activation of these tasks as a functional magnetic resonance imaging (fMRI) paradigm in brain tumor patients. Material andMethods:
The behavioral performance (correct responses and reaction time) of three language tasks (verbal fluency, semantic and phonological decision tasks) was first examined in 76 healthy volunteers balanced by age and educational level. Later, these tasks were implemented as fMRI paradigms to explore CCC language activation of 20 patients with potential diagnosis of brain tumors.Results:
The performance of the verbal fluency task was affected by age. The CCC language activation was reproducible with the semantic and phonological tasks. The combination of the tasks determined typical and atypical language lateralization in 60% and 40% of our patients, respectively.Conclusions:
The verbal fluency task must be implemented with care as a clinical fMRI paradigm. Our results suggest that semantic and phonological tasks can be a good alternative for brain tumor patients with language deficits.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Brain Neoplasms
/
Language
Type of study:
Prognostic study
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2021
Type:
Article
Affiliation country:
Chile
/
Colombia
Institution/Affiliation country:
Complejo Asistencial Doctor Sótero del Río/CL
/
Hospital Barros Luco Trudeau/CL
/
Hospital Base de Puerto Montt/CL
/
Universidad Andrés Bello/CL
/
Universidad Católica Silva Henríquez/CL
/
Universidad Católica de Chile/CL
/
Universidad Santo Tomás/CL
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