Factores de riesgo cardiometabólico y funcionamiento cognitivo: el rol de la reserva cognitiva / Association between cardiometabolic risk and cognitive impairment
Rev. méd. Chile
;
149(8): 1134-1140, ago. 2021. ilus
Article
in Spanish
| LILACS
| ID: biblio-1389574
ABSTRACT
Background:
Several risk factors are associated with cognitive impairment in older people, but little attention has been paid to cardiometabolic variables, as well as how cognitive reserve can mediate this association.Aim:
To determine the association of cardiometabolic risk factors with cognitive functioning and whether the cognitive reserve mediates this association. Material andMethods:
A cross-sectional study with 300 participants with a median age of 56 years (53% male) was conducted. Participants had a cognitive functioning assessment. Fasting glucose, HDL-cholesterol, and blood pressure were measured.Results:
A Structural Equation Modeling, revealed a direct effect of cardiometabolic latent risk factors on both a cognitive functioning (β = -.204; p = .056), and cognitive reserve factors (β = -.236, p = .04). Cognitive reserve was directly associated with cognitive functioning (β = .327, p = .01), but did not mediate the association between the cardiometabolic risk factors and cognitive functioning (β = .077, p = .07). The overall goodness of fitness was excellent χ2 (50) = 58.357, p = .195, comparative fit index = .980, Tucker-Lewis Index = .974, root mean square error of approximation = .023 and Standardized Root Mean Square Residual = .041.Conclusions:
A direct effect of cardiometabolic risk factors on cognitive functioning was observed.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Cardiovascular Diseases
/
Cognitive Reserve
/
Cognitive Dysfunction
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2021
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de La Frontera/CL
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