Intercambio plasmático terapéutico por plasmafiltración: experiencia de 11 años de un centro / Therapeutic plasma exchange: experience in 102 patients
Rev. méd. Chile
;
150(2): 147-153, feb. 2022. tab
Article
in Spanish
| LILACS
| ID: biblio-1389630
ABSTRACT
BACKGROUND:
Therapeutic Plasma Exchange (TPE) is a procedure in which plasma and harmful macromolecules are separated from the rest of the blood components by centrifugation or filtration through membranes and are replaced with solutions with albumin and/or plasma.AIM:
To communicate our experience using TPE by filtration. MATERIAL ANDMETHODS:
Review of records of 655 TPE sessions performed in 102 patients aged 50 ± 18 years (64% women). The requirement of renal replacement therapy (RRT) and seven days and one year mortality were recorded.RESULTS:
Forty five percent of patients had hypertension or diabetes. The main indications for TPE were pulmonary-renal syndrome (PRS) (62%) and antibody mediated graft rejection (29%), followed by neurological diseases (36%). Fifteen percent of patients required RRT for one year. Mortality at seven days and one year was 20 and 30%, respectively. Out of the total of deaths associated with kidney diseases, 88% corresponded to PRS and ANCA vasculitis. The main complications were thrombocytopenia in 41%, hypocalcemia in 18%, and hypotension in 16%.CONCLUSIONS:
In our experience, TPE by filtration is a safe technique, with mild and preventable complications. Despite this, the reported mortality is high, which reflects the severity of the diseases that motivated the indication for TPE.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plasma Exchange
/
Antibodies, Antineutrophil Cytoplasmic
Type of study:
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2022
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Carlos Van Buren/CL
/
Universidad de Atacama/CL
/
Universidad de Concepción/CL
Similar
MEDLINE
...
LILACS
LIS