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Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid membrane
Doval Neto, José; Marques, Rodrigo Fernando Costa; Motta, Adriana Cristina; Duek, Eliana Aparecida de Rezende; Oliveira, Guilherme José Pimentel Lopes de; Marcantonio, Cláudio.
  • Doval Neto, José; Araraquara University Center. Araraquara Dental School. Department of Postgraduate Studies in Implantology. Araraquara. BR
  • Marques, Rodrigo Fernando Costa; Paulista State University. Institute of Chemistry. Araraquara. BR
  • Motta, Adriana Cristina; Pontifical Catholic University of São Paulo. Faculty of Medical Sciences and Health. Biomaterials Laboratory. Sorocaba. BR
  • Duek, Eliana Aparecida de Rezende; Pontifical Catholic University of São Paulo. Faculty of Medical Sciences and Health. Biomaterials Laboratory. Sorocaba. BR
  • Oliveira, Guilherme José Pimentel Lopes de; Federal University of Uberlândia. School of Dentistry. Department of Periodontology/Implantodontology. Uberlândia. BR
  • Marcantonio, Cláudio; Araraquara University Center. Araraquara Dental School. Department of Postgraduate Studies in Implantology. Araraquara. BR
Braz. j. oral sci ; 21: e220616, jan.-dez. 2022. ilus
Article in English | LILACS, BBO | ID: biblio-1393329
ABSTRACT
The use of selective barriers as resorbable membranes has become a routine clinical procedure for guided bone regeneration. Therefore, the production of membranes with a low inflammatory potential during their resorption process has become the goal of a considerable number of researches.

Aim:

The purpose of the present study was to evaluate the biocompatibility of poly (L- lactic acid) (PLLA) and biocelulose membranes (BC) inserted in the subcutaneous tissue on the dorsum of rats.

Methods:

Fifteen animals underwent surgical procedures for the insertion of 4 types of membranes COL (Collagen membrane) ­ Control Group; BC (Biocellulose membrane); BCAg (Biocellulose membrane impregnated with Silver); PLLA (Poly (L-lactic acid) membrane). All membrane types were inserted into each animal. Animals were euthanized after 3, 7, and 15 days of the surgical procedure. Descriptive histological analyses were carried out to investigate host tissue reaction to membrane presence by assessing the anti-inflammatory process composition associated with the membrane resorption and the presence of foreign-body reaction or encapsulation.

Results:

The BC membranes showed a higher degree of inflammation and poor pattern of integration with the surrounding tissues than the PLLA and COL membranes.

Conclusion:

The PLLA and COL membranes present better biocompatibility than the BC membranes
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Biocompatible Materials / Bone Regeneration / Materials Testing / Lactic Acid / Subcutaneous Tissue / Membranes Limits: Animals Language: English Journal: Braz. j. oral sci Journal subject: Dentistry Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Araraquara University Center/BR / Federal University of Uberlândia/BR / Paulista State University/BR / Pontifical Catholic University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Biocompatible Materials / Bone Regeneration / Materials Testing / Lactic Acid / Subcutaneous Tissue / Membranes Limits: Animals Language: English Journal: Braz. j. oral sci Journal subject: Dentistry Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Araraquara University Center/BR / Federal University of Uberlândia/BR / Paulista State University/BR / Pontifical Catholic University of São Paulo/BR