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Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression
Gaggero, Gabriele; Campora, Michela; Taietti, Davide; Cerruti, Giannamaria; Lo Bue, Enrico; Truffelli, Monica; Ceraudo, Marco; Fiaschi, Pietro.
  • Gaggero, Gabriele; Ospedale Policlinico San Martino. Pathology Unit. Genoa. IT
  • Campora, Michela; Public Healthcare Trust of the Autonomous Province of Trento. Santa Chiara Hospital. Department of Laboratory Medicine, Pathology Unit. Trento. IT
  • Taietti, Davide; Azienda Socio Sanitaria Territoriale. Ospedale Maggiore. Anatomic Pathology Unit. Crema. IT
  • Cerruti, Giannamaria; Ospedale Policlinico San Martino. Molecular Diagnostic Unit. Genoa. IT
  • Lo Bue, Enrico; Ospedale Policlinico San Martino. Division of Neurosurgery. Genoa. IT
  • Truffelli, Monica; Ospedale Policlinico San Martino. Division of Neurosurgery. Genoa. IT
  • Ceraudo, Marco; Ospedale Policlinico San Martino. Division of Neurosurgery. Genoa. IT
  • Fiaschi, Pietro; University of Genoa. Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health. Genoa. IT
Autops. Case Rep ; 12: e2021394, 2022. graf
Article in English | LILACS-Express | LILACS | ID: biblio-1393987
ABSTRACT
ABSTRACT Lymphoplasmacyte-rich meningioma (LPRM) is one of the rarest variants of grade I meningiomas. It can be clinically associated with prominent peripheral blood abnormalities, anemia, and/or various gammopathy, which usually disappear after surgical removal of the tumor. We document a case of right frontal LPRM in a 72-year-old male who presented general cognitive decadence. The patient suffered from mild anemia. The LPRM is a rare variant of meningioma, with only a few cases globally reported in the literature. It has been categorized as a grade I tumor in the 2021 World Health Organization (WHO) classification central nervous system. Due to the rarity, this meningioma variant origin and biological behavior are still not clear. Immunohistochemistry profile showed prominent PD-L1 expression, leading to additional interrogation on LPRM immunomorphological characteristics, the significance of the inflammatory tumoral microenvironment and its correlation with the immune-checkpoints.


Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2022 Type: Article Affiliation country: Italy Institution/Affiliation country: Azienda Socio Sanitaria Territoriale/IT / Ospedale Policlinico San Martino/IT / Public Healthcare Trust of the Autonomous Province of Trento/IT / University of Genoa/IT

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Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2022 Type: Article Affiliation country: Italy Institution/Affiliation country: Azienda Socio Sanitaria Territoriale/IT / Ospedale Policlinico San Martino/IT / Public Healthcare Trust of the Autonomous Province of Trento/IT / University of Genoa/IT