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Direct-acting antivirals for chronic Hepatitis C are effective and safe: an observational study in Londrina/PR
Machado, Hodnei Takashi; Guidoni, Camilo Molino.
  • Machado, Hodnei Takashi; Paraná State Secretary of Health. Specialized Pharmacy of Londrina. Londrina. BR
  • Guidoni, Camilo Molino; State University of Londrina. Department of Pharmaceutical Sciences. Londrina. BR
Braz. J. Pharm. Sci. (Online) ; 58: e19925, 2022. tab
Article in English | LILACS | ID: biblio-1394039
ABSTRACT
Abstract This study aimed to evaluate the effectiveness and safety of direct-acting antivirals in a Unified Health System pharmacy of Londrina, Brazil. A descriptive observational study was performed from June 2017 to June 2018. Sociodemographic, clinical, and therapeutic variables of patients were collected from secondary data sources. Effectiveness was evaluated by sustained virologic response (SVR) and safety was evaluated by adverse events (AEs) and drug interactions (DIs). The mean population (N=30) was 56.6±11.3 years old and almost all patients had comorbidities (93.3%) and concomitant drugs (96.7%). Effectiveness evaluation was possible in 17 patients, and all of them (100.0%) achieved SVR. Eighteen patients (60.0%) reported 38 AEs, mostly mild, such as stomach symptoms and headache. No statistical relation was found between AE occurrence and treatment duration, Ribavirin use, number of comorbidities or number of concomitant drugs. A total of 48 DIs were reported, 18 being severe, and were managed by the pharmacist. The study indicates that the treatment was effective and safe.
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Full text: Available Index: LILACS (Americas) Main subject: Antiviral Agents / Efficacy / Hepatitis C, Chronic / Insurance Type of study: Observational study Limits: Adult / Female / Humans / Male Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Paraná State Secretary of Health/BR / State University of Londrina/BR

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Full text: Available Index: LILACS (Americas) Main subject: Antiviral Agents / Efficacy / Hepatitis C, Chronic / Insurance Type of study: Observational study Limits: Adult / Female / Humans / Male Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Paraná State Secretary of Health/BR / State University of Londrina/BR