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Biomarker potential of hsa-miR-145-5p in peripheral whole blood of manic bipolar I patients
Tekin, Sevinç Sürer; Erdal, Mehmet Emin; Asoğlu, Mehmet; Ay, Özlem İzci; Ay, Mustafa Ertan; Yılmaz, Şenay Görücü.
  • Tekin, Sevinç Sürer; Mersin University Faculty of Medicine. Department of Medical Biology. Mersin. TR
  • Erdal, Mehmet Emin; Mersin University Faculty of Medicine. Department of Medical Biology. Mersin. TR
  • Asoğlu, Mehmet; Harran University Faculty of Medicine. Department of Psychiatry. Şanlıurfa. TR
  • Ay, Özlem İzci; Mersin University Faculty of Medicine. Department of Medical Biology. Mersin. TR
  • Ay, Mustafa Ertan; Mersin University Faculty of Medicine. Department of Medical Biology. Mersin. TR
  • Yılmaz, Şenay Görücü; Gaziantep University Faculty of Health Science. Department of Nutrition and Dietetics. Gaziantep. TR
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 44(4): 378-387, July-Aug. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1394072
ABSTRACT

Objective:

Bipolar I disorder (BD-I) is a type of bipolar spectrum disorder characterized by manic or mixed episodes. Detecting microRNA regulations as epigenetic actors in BD-I is important to elucidate the pathogenesis of the disease and reveal the potential of microRNAs (miRNAs) as biomarkers.

Methods:

We evaluated the expression profile of six candidate miRNAs (hsa-miR-145-5p, hsa-miR-376a-3p, hsa-miR-3680-5p, hsa-miR-4253-5p, hsa-miR-4482-3p, and hsa-miR-4725) in patients with BD-I and in healthy controls (aged 11-50 years). We also determined the potential target genes of these miRNAs through in silico analysis. The diagnostic values of the miRNAs were calculated through receiver operating characteristic curve analysis.

Results:

Four miRNAs were upregulated (hsa-miR-376a-3p, hsa-miR-3680-5p, hsa-miR-4253-5p, hsa-miR-4482-3p) and hsa-miR-145-5p was downregulated in patients (p < 0.001). The target gene analyses showed that hsa-miR-145-5p specifically targets the dopamine decarboxylase (DDC) gene. The area under the curve of hsa-miR-145-5p was 0.987.

Conclusion:

Differential expression of five miRNAs in peripheral blood may be associated with the pathogenesis of BD-I, and hsa-miR-145-5p has potential as a BD-I biomarker. This miRNA can be used in dopamine-serotonin regulation and dose adjustment in drug therapy via the DDC gene.


Full text: Available Index: LILACS (Americas) Type of study: Prognostic study Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2022 Type: Article Affiliation country: Turkey Institution/Affiliation country: Gaziantep University Faculty of Health Science/TR / Harran University Faculty of Medicine/TR / Mersin University Faculty of Medicine/TR

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Full text: Available Index: LILACS (Americas) Type of study: Prognostic study Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2022 Type: Article Affiliation country: Turkey Institution/Affiliation country: Gaziantep University Faculty of Health Science/TR / Harran University Faculty of Medicine/TR / Mersin University Faculty of Medicine/TR