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Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4
Jiang, Haibing; Ge, Zhengrong; Zhang, Lijing; Yang, Yi; Zhai, Xueqin; Chen, Zhanxi; Wei, Qing.
  • Jiang, Haibing; Medical University. Hospital of Xinjiang. Department of Cardiology. Urumqi. CN
  • Ge, Zhengrong; Medical University. Hospital of Xinjiang. Department of Cardiology. Urumqi. CN
  • Zhang, Lijing; Medical University. Hospital of Xinjiang. Department of Cardiology. Urumqi. CN
  • Yang, Yi; Medical University. Hospital of Xinjiang. Department of Cardiology. Urumqi. CN
  • Zhai, Xueqin; Medical University. Hospital of Xinjiang. Department of Cardiology. Urumqi. CN
  • Chen, Zhanxi; Medical University. Hospital of Xinjiang. Department of Cardiology. Urumqi. CN
  • Wei, Qing; Medical University. Hospital of Xinjiang. Department of Cardiology. Urumqi. CN
Rev. bras. cir. cardiovasc ; 37(4): 525-533, Jul.-Aug. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1394742
ABSTRACT
Abstract

Introduction:

This study investigated the correlation between the levels of long noncoding ribonucleic acids (lncRNAs) AF131217.1 and coronary slow flow (CSF).

Methods:

A total of 22 patients in the high-sensitivity C-reactive protein (hsCRP) group diagnosed with CSF from January 2018 to December 2018 were enrolled in this study. Coronary flow velocity was determined using the thrombolysis in myocardial infarction frame count (TFC) method.

Results:

LncRNA AF131217.1 expression in the CSF model was activated. Mean TFC was positively correlated with lncRNA AF131217.1 levels and hsCRP levels. LncRNA AF131217.1 induced inflammation factor levels in the in vitro model. Micro ribonucleic acid (miR)-128-3p is a target spot of lncRNA AF131217.1 on the inflammation in vitro model via Kruppel-like factor (KLF) 4. MiR-128-3p reduced inflammation factor levels (tumor necrosis factor alpha, interleukin [IL]-6, IL-1β, and IL-18).

Conclusion:

Thus, lncRNA AF131217.1 promoted inflammation in the regulated CSF via KLF4 by miR-128-3p.


Full text: Available Index: LILACS (Americas) Type of study: Prognostic study Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2022 Type: Article Affiliation country: China Institution/Affiliation country: Medical University/CN

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Full text: Available Index: LILACS (Americas) Type of study: Prognostic study Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2022 Type: Article Affiliation country: China Institution/Affiliation country: Medical University/CN