Effects of Bacillus firmus e volumine ex muris cellulae 6x on cytolytic activity of natural killer cells in vitro
Int. j. high dilution res
;
20(2/3): 34-43, June 4, 2021.
Article
in English
| LILACS, HomeoIndex
| ID: biblio-1396358
ABSTRACT
Natural killer (NK) cells are among the first in defense of the innate immune system by eliminating a variety of abnormal or stressed cells such as cancer cells or virus-infected cells. Individuals who exhibit low cytolytic NK cell activity are believed to be at higher risk of viral infection, tumorigenesis, and various other diseases of the immune system. Therefore, restoration of impaired NK cell function might be an essential step in immunostimulatory therapy of immunocompromised patients. Bacillus firmus is a non-pathogenic gram-positive bacterium of the environment, which possesses various immunomodulatory properties in vitro and in vivo. This retrospective study reports on the effect of B. firmus on the activity of NK cells in vitro. Basal cytolytic NK cell activity against tumor cells among peripheral blood mononuclear cells (PBMCs) of routine patients was determined in a standardized NK cell cytotoxicity assay. The impact of cultivation of PBMCs with B. firmus preparation Bacillus firmus e volumine ex muris cellulae (Bacillus firmus (evc)) 6x on tumor cell killing by NK cells was monitored in relation to basal NK cell activity. This study showed that stimulation of PBMCs with Bacillus firmus (evc) 6x in vitro led to a significant increase in NK cell function. Substantial improvement in cytolytic NK cell activity (more than 1.3-fold of basal activity) was much more pronounced for patients with compromised NK cell function. Due to its immunostimulatory mode of action, Bacillus firmus (evc) may be of particular importance in therapy of patients with NK cell deficiency.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Killer Cells, Natural
/
K562 Cells
/
Bacillus firmus
Type of study:
Observational study
/
Risk factors
Language:
English
Journal:
Int. j. high dilution res
Journal subject:
Homeopathy
/
Terapias Complementares
Year:
2021
Type:
Article
Affiliation country:
Germany
Institution/Affiliation country:
GANZIMMUN Diagnostics AG/DE
/
SANUM-Kehlbeck GmbH & Co.KG/DE
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