Metabolic syndrome and its components among HIV/AIDS patients on Antiretroviral Therapy and ART-Naïve Patients at the University of Calabar Teaching Hospital, Calabar, Nigeria
African Health Sciences
;
22(1): 410-417, March 2022. Tables
Article
in English
| AIM
| ID: biblio-1400643
ABSTRACT
Background:
Although an increasing access to ART in sub-Saharan Africa has made it possible for HIV/AIDS patients to live longer, clinicians managing such patients are faced with the challenge of drug-related metabolic complications.Methods:
A cross -sectional study was carried out at the University of Calabar Teaching Hospital, Nigeria, on three groups of participants; namely HIV patients on ART, ART-naïve patients and HIV negative subjects (n =75). Demographic and anthropometric data were collected using a well-structured questionnaire while biochemical parameters were measured using colorimetric methods.Results:
The highest prevalence of MS was associated with the HIV/AIDS patients on ART (i.e. 32.0 %, and 50.3% for NCEP-ATP III and IDF criteria respectively). Patients on ART had significant increases (p< 0.05) in waist to hip ratio, FPG, serum TG and LDL-c; and a significantly higher (p< 0.05) prevalence of hypertension, diabetes, low HDL-c and hypertriglyceridemia compared to the ART-naïve patients. Low serum HDL-c was the most prevalent form of dyslipidemia in all three groups and the most prevalent component of MS in HIV patients.Conclusion:
ART increases the risk of MS and CVD. HIV/AIDS patients on ART should be advised on lifestyle modifications and undertake regular assessment of their cardiovascular risk factors
Full text:
Available
Index:
AIM (Africa)
Main subject:
Patients
/
Acquired Immunodeficiency Syndrome
/
HIV
/
Antiretroviral Therapy, Highly Active
/
Activation, Metabolic
Type of study:
Observational study
/
Qualitative research
/
Risk factors
Country/Region as subject:
Africa
Language:
English
Journal:
African Health Sciences
Year:
2022
Type:
Article
Institution/Affiliation country:
Akwa Ibom State Hospital Management Board, Uyo, Nigeria, Akwa Ibom State Hospital Management Board/NG
/
University of Buea , Medical Laboratory Sciences/NG
/
University of Buea, Cameroon, Medical Laboratory Sciences/NG
/
University of Calabar, Nigeria, Medical Laboratory Sciences/NG
/
University of Calabar, Nigeria, Medical Laboratory Sciences, Faculty of Allied Medical Sciences/NG
/
University of calabar, department of medical laboratory science/NG
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