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Drotaverine to shorten the duration of labour in primigravidas: a randomised, double-blind, placebo-controlled trial
Chidiebele Ikeotuonye, Arinze; Odidika, Johannes Umeora; Ifunanya Nwafor, Johnbosco; Omuye Ojumah, Bonaventure; Ekwunife, Ifeoma Cecilia; Ikechukwu, Bonaventure Dimejesi.
  • Chidiebele Ikeotuonye, Arinze; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, South-east, Nigeria. Abakaliki. NG
  • Odidika, Johannes Umeora; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, South-east, Nigeria. Abakaliki. NG
  • Ifunanya Nwafor, Johnbosco; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, South-east, Nigeria. Abakaliki. NG
  • Omuye Ojumah, Bonaventure; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, South-east, Nigeria. Abakaliki. NG
  • Ekwunife, Ifeoma Cecilia; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, South-east, Nigeria. Abakaliki. NG
  • Ikechukwu, Bonaventure Dimejesi; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, South-east, Nigeria. Abakaliki. NG
African Health Sciences ; 22(3): 108-116, 2022-10-26. Figures, Tables
Article in English | AIM | ID: biblio-1401066
ABSTRACT

Background:

Drotaverine, a spasmolytic, has been found to have potential to achieve a reduction in the duration of labor and prevent prolonged labor.

Objective:

To compare the effects of intravenous drotaverine hydrochloride with placebo for shortening the duration of active phase of labor in primigravida's.

Methods:

A double-blind, placebo-controlled randomized trial of 246 primigravida's in active phase of labor at term was conducted. They were randomly (11 ratio) administered intravenous 2 ml (40mg) of drotaverine hydrochloride or 2 ml of Vitamin B complex as placebo. The primary outcome measure was the duration of active phase of labor. The secondary outcome measures were cervical dilatation rate, oxytocin augmentation rate, incidence of prolonged labor, labor pain scores, mode of delivery, maternal and neonatal outcomes.

Results:

The mean duration of active phase of labor (hour) was significantly lower in the drotaverine group compared to the control (drotaverine; 6.22 ± 2.41 vs placebo; 8.33 ± 3.56; p <0.001). Also, the cervical dilatation rate (cm/hr) was significantly faster in the drotaverine arm (drotaverine; 1.68 ± 1.02 versus placebo; 1.06 ± 0.53, p <0.001). There was a significantly higher probability of faster delivery among women who were given drotaverine (log-rank test, p < 0.001). The oxytocin augmentation rate, incidence of prolonged labor, labor pain scores, mode of delivery, maternal and neonatal outcomes were not significantly different among the groups.

Conclusions:

Drotaverine hydrochloride is effective in shortening the duration of active phase of labor without adverse maternal and neonatal outcomes. However, more evidence is needed to explore its role in active phase of labor among primigravid women. Trial registration number PACTR201810902005232
Subject(s)

Full text: Available Index: AIM (Africa) Main subject: Parasympatholytics / Placebos / Clinical Laboratory Techniques / Duration of Therapy Type of study: Controlled clinical trial / Diagnostic study Country/Region as subject: Africa Language: English Journal: African Health Sciences Year: 2022 Type: Article Institution/Affiliation country: Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, South-east, Nigeria/NG

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Full text: Available Index: AIM (Africa) Main subject: Parasympatholytics / Placebos / Clinical Laboratory Techniques / Duration of Therapy Type of study: Controlled clinical trial / Diagnostic study Country/Region as subject: Africa Language: English Journal: African Health Sciences Year: 2022 Type: Article Institution/Affiliation country: Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, South-east, Nigeria/NG