Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus
African Health Sciences
;
22(3): 296-306, 2022-10-26. Tables
Article
in English
| AIM
| ID: biblio-1401337
ABSTRACT
Background:
Diabetes mellitus is a chronic and progressive endocrine disorder that may result in macro and microvascular complications.Objective:
This study assessed some biochemical analytes in Nigerians who were recently (≤ 6 months) diagnosed with Type 2 diabetes mellitus (T2DM).Methods:
160 T2DM and 90 non-diabetic control participated in this study. Blood samples were collected and analyzed for Heart-type fatty acid-binding protein (HFABP), high sensitivity C-reactive protein (hs-CRP), electrolytes, lipid and renal profile parameters, glycated haemoglobin (HBA1C) and fasting blood glucose (FBG), using standard guidelines.Result:
The body mass index (BMI) of the T2DM volunteers was higher than control (P <0.001). The lipid profile, potassium, glucose, HBA1C, urea and creatinine values were elevated (P <0.001) while estimated glomerular filtration rate (eGFR) was lower (P<0.05) in diabetes. The median HFABP and hs-CRP were raised (P <0.05) in T2DM. Positive associations existed between FBG and urea (P <0.001), Creatinine and HBAIC (P <0.001). A logistic regression analysis, shows that an increased BMI, HBA1C, FBG, Cholesterol, urea and creatinine were associated with higher odds (p<0.001) of cardiovascular and renal complications.Conclusion:
Elevated hs-CRP, glycated haemoglobin, urea and creatinine among T2DM increase the odds of cardiovascular and renal insults in this population
Full text:
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Index:
AIM (Africa)
Main subject:
Glycated Hemoglobin
/
Diabetes Mellitus, Type 2
/
Renal Insufficiency, Chronic
Type of study:
Practice guideline
Country/Region as subject:
Africa
Language:
English
Journal:
African Health Sciences
Year:
2022
Type:
Article
Institution/Affiliation country:
. Department of Haematology and Blood group Serology, College of Medicine University of Lagos/NG
/
Department of Medical Laboratory Science, College of Medicine University of Lagos/NG
/
Department of Medical Laboratory science Babcock University Ilishan Remo, Ogun State/NG
/
School of Medical Laboratory Science, Lagos University Teaching Hospital/NG
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