Indirect serum biomarkers perform sub optimally in screening for significant liver fibrosis among HIV-infected and uninfected adults in Uganda
African Health Sciences
;
22(3): 416-425, 2022-10-26. Figures, Tables
Article
in English
| AIM
| ID: biblio-1401351
ABSTRACT
ntroduction Indirect serum biomarkers present an acceptable noninvasive and cheap alternative for screening of significant liver fibrosis (SLF). Evaluation of their use in resource limited settings is important to determine their utility. Methods:
We conducted a cross sectional study among 520 HIV infected and HIV uninfected adults attending care clinics in Kampala Uganda. Presence of SLF was determined using Fibroscan® liver stiffness measurement of ≥7.2KPa. The diagnostic value of indirect serum biomarkers for diagnosis of SLF was evaluated using the area under the receiver operating characteristics curve (AUROC) using Fibroscan® as gold standard.Results:
Overall AUROC values for Age Platelet Index (API), Aspartate to Alanine Ratio (AAR), AST-to-Platelet Ratio Index (APRI), Fibrosis Index based on 4 Factors (FIB-4) and Gamma glutamyl transferase to Platelet Ratio Index (GPR) were 0.52, 0.49, 0.55, 0.55 and 0.54 respectively. Among HIV-infected participants AUROC values were slightly improved at predicting presence of SLF but still under 70%.Conclusion:
Despite APRI and FIB-4 being more likely to identify participants with SLF, the overall diagnostic value of all serum biomarkers was poor with and without stratification by HIV status. We recommend the use of Fibroscan® technology as more accurate non-invasive diagnostic method for screening of SLF
Full text:
Available
Index:
AIM (Africa)
Main subject:
Mass Screening
/
Acquired Immunodeficiency Syndrome
/
HIV Testing
/
Liver Cirrhosis
Type of study:
Diagnostic study
/
Observational study
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Prognostic study
/
Risk factors
/
Screening study
Country/Region as subject:
Africa
Language:
English
Journal:
African Health Sciences
Year:
2022
Type:
Article
Institution/Affiliation country:
Cambridge University, Institute of Public Health, Cambridge UK/GB
/
Infectious Diseases Institute, Makerere University Kampala Uganda/UG
/
John Hopkins University, Baltimore USA/US
/
Makerere University, College of Health Sciences Kampala Uganda/UG
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