Mesenchymal stem cells have ameliorative effect on the colitis model via Nrf2/HO-1 pathway
Acta cir. bras
;
37(7): e370704, 2022. tab, ilus
Article
in English
| LILACS, VETINDEX
| ID: biblio-1402971
ABSTRACT
Purpose:
To evaluate the ameliorative effect of mesenchymal stem cells (MSCs) on acetic acid colitis model via Nrf2/HO-1 pathway in rats.Methods:
In this study, 30 rats were divided into three groups. Acute colitis was induced by rectal administration of 4% solution of acetic acid. MSCs were injected intraperitoneally in the treatment group.Results:
Increased levels of tumor necrosis factor-α (TNF-α), pentraxin-3, and malondialdehyde (MDA) in colitis group were revealed biochemically. Increased level of TNF-α and decreased levels of Nrf2 and interleukin-10 (IL-10) were observed in rectum tissues. Increased fibrous tissue proliferation, vascularization and inflammatory cell infiltration were described in the colitis group. Significant improvement was observed in MSCs treated group histopathologically. Increased immunopositivity of TNF-α, vascular endothelial growth factor (VEGF) and CD68 markers was observed in the colitis group cells, and decreased level of this positivity was observed in MSCs treated group.Conclusions:
Biochemical, histopathological and immunohistochemical results strongly support the ameliorative effect of MSCs against acetic induced colitis model via Nrf2/HO-1 pathway in rats.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Colitis
/
Acetic Acid
/
Vascular Endothelial Growth Factor A
/
NF-E2-Related Factor 2
/
Mesenchymal Stem Cells
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Year:
2022
Type:
Article
Institution/Affiliation country:
Afyon Kocatepe University/TR
/
Demiroglu Bilim University/TR
/
Istanbul Florence Nightingale Hospital/TR
/
Stembio Cell and Tissue Technologies Inc/TR
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