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Mesenchymal stem cells have ameliorative effect on the colitis model via Nrf2/HO-1 pathway
Bozkurt, Mehmet Fatih; Bhaya, Muhammed Nasir; Dibekoglu, Cengiz; Akat, Ayberk; Ates, Utku; Erbas, Oytun.
  • Bozkurt, Mehmet Fatih; Afyon Kocatepe University. Faculty of Veterinary Medicine. Department of Pathology. Afyonkarahisar. TR
  • Bhaya, Muhammed Nasir; Afyon Kocatepe University. Faculty of Veterinary Medicine. Department of Pathology. Afyonkarahisar. TR
  • Dibekoglu, Cengiz; Istanbul Florence Nightingale Hospital. Department of General Surgery. Istanbul. TR
  • Akat, Ayberk; Stembio Cell and Tissue Technologies Inc. Istanbul. TR
  • Ates, Utku; Stembio Cell and Tissue Technologies Inc. Istanbul. TR
  • Erbas, Oytun; Demiroglu Bilim University. Cephalink Institute. Department of Physiology. Gebze. TR
Acta cir. bras ; 37(7): e370704, 2022. tab, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1402971
ABSTRACT

Purpose:

To evaluate the ameliorative effect of mesenchymal stem cells (MSCs) on acetic acid colitis model via Nrf2/HO-1 pathway in rats.

Methods:

In this study, 30 rats were divided into three groups. Acute colitis was induced by rectal administration of 4% solution of acetic acid. MSCs were injected intraperitoneally in the treatment group.

Results:

Increased levels of tumor necrosis factor-α (TNF-α), pentraxin-3, and malondialdehyde (MDA) in colitis group were revealed biochemically. Increased level of TNF-α and decreased levels of Nrf2 and interleukin-10 (IL-10) were observed in rectum tissues. Increased fibrous tissue proliferation, vascularization and inflammatory cell infiltration were described in the colitis group. Significant improvement was observed in MSCs treated group histopathologically. Increased immunopositivity of TNF-α, vascular endothelial growth factor (VEGF) and CD68 markers was observed in the colitis group cells, and decreased level of this positivity was observed in MSCs treated group.

Conclusions:

Biochemical, histopathological and immunohistochemical results strongly support the ameliorative effect of MSCs against acetic induced colitis model via Nrf2/HO-1 pathway in rats.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Colitis / Acetic Acid / Vascular Endothelial Growth Factor A / NF-E2-Related Factor 2 / Mesenchymal Stem Cells Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Year: 2022 Type: Article Institution/Affiliation country: Afyon Kocatepe University/TR / Demiroglu Bilim University/TR / Istanbul Florence Nightingale Hospital/TR / Stembio Cell and Tissue Technologies Inc/TR

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Full text: Available Index: LILACS (Americas) Main subject: Colitis / Acetic Acid / Vascular Endothelial Growth Factor A / NF-E2-Related Factor 2 / Mesenchymal Stem Cells Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Year: 2022 Type: Article Institution/Affiliation country: Afyon Kocatepe University/TR / Demiroglu Bilim University/TR / Istanbul Florence Nightingale Hospital/TR / Stembio Cell and Tissue Technologies Inc/TR