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Aumento da Espessura Médio-intimal Aórtica e sua Relação com Estresse Oxidativo Elevado em Pacientes com Talassemia Menor / Aortic Intima Media Thickness is Increased and Closely Related to Elevated Oxidative Stress Increases in Beta Thalassemia Minor
Tumer, Cansu; Saler, Tayyibe; Aslan, Muhammed Zubeyir; Koc, Ayse Selcan; Koc, Mevlüt; Erel, Ozcan; Neselioglu, Salim; Gulumsek, Erdinc; Avci, Begum Seyda; Avci, Akkan; Sumbul, Hilmi Erdem.
  • Tumer, Cansu; Adana Health Practice and Research Center. Adana. TR
  • Saler, Tayyibe; Adana Health Practice and Research Center. Adana. TR
  • Aslan, Muhammed Zubeyir; Adana Health Practice and Research Center. Adana. TR
  • Koc, Ayse Selcan; Adana Health Practice and Research Center. Adana. TR
  • Koc, Mevlüt; Adana Health Practice and Research Center. Adana. TR
  • Erel, Ozcan; University of Yıldırım Beyazıt. Department of Medical Biochemistry. Ankara. TR
  • Neselioglu, Salim; University of Yıldırım Beyazıt. Department of Medical Biochemistry. Ankara. TR
  • Gulumsek, Erdinc; Adana Health Practice and Research Center. Adana. TR
  • Avci, Begum Seyda; Adana Health Practice and Research Center. Adana. TR
  • Avci, Akkan; Adana Health Practice and Research Center. Adana. TR
  • Sumbul, Hilmi Erdem; Adana Health Practice and Research Center. Adana. TR
Arq. bras. cardiol ; 119(3): 426-435, set. 2022. tab, graf
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1403344
RESUMO
Resumo Fundamento A espessura médio-intimal (EMI) da artéria aorta abdominal (EMI-A) pode ser um marcador precoce de aterosclerose subclínica e um indicador objetivo de estresse oxidativo em pacientes com talassemia menor. Objetivo Avaliar se as EMIs da artéria aorta e da artéria carótida (EMI-C) se alteram com estresse oxidativo, e examinar a relação entre esses parâmetros em pacientes com talassemia menor. Métodos O estudo incluiu 80 pacientes diagnosticados com talassemia menor, e 50 indivíduos sadios com idade e sexo similares. Após procedimentos de rotina, as amostras de sangue foram coletadas dos grupos de estudo para a medida da homeostase tiol/dissulfeto e da albumina modificada pela isquemia (AMI). As medidas da EMI-C foram realizadas a partir de quatro regiões diferentes (artéria carótida externa direita e esquerda e artéria carótida interna direita e esquerda) por ultrassonografia, e a medida da EMI-A foi realizada por ultrassonografia abdominal. Um valor de p<0,05 foi definido como estatisticamente significativo. Resultados Nos pacientes com talassemia menor, os níveis de tiol nativo e tiol total, e a razão tiol nativo/tiol total foram mais baixos, e os valores de AMI, razão dissulfeto/tiol nativo, e razão dissulfeto/tiol total foram mais altos que no grupo controle. A EMI-A foi significativamente maior no grupo de pacientes com talassemia menor que nos controles (1,46±0,37 vs 1,23±0,22 e p<0,001). Quando os parâmetros associados com EMI-A na análise univariada foram avaliados por regressão linear multivariada, EMI-A apresentou uma relação positiva, e os níveis de tiol nativo e tiol total apresentaram uma forte relação negativa com AMI (p<0,01). Conclusão Nós demonstramos, pela primeira vez, um aumento no estresse oxidativo com a elevação da EMI-A, e valores inalterados da EMI-C em pacientes com talassemia menor.
ABSTRACT
Abstract Background Abdominal aortic intima media thickness (A-IMT) may be an early marker of subclinical atherosclerosis and an objective indicator of increased oxidative stress in beta-thalassemia minor patients. Objective To evaluate whether aortic and carotid IMTs change with oxidative stress and to assess the relationship between these parameters in beta-thalassemia minor patients. Methods The study included 80 patients diagnosed with beta-thalassemia minor, and 50 healthy individuals with similar age and gender. After routine procedures, blood samples were collected from the study groups for thiol-disulfide hemostasis and ischemia-modified albumin (IMA). C-IMT measurements were performed in four different regions (right and left internal and external carotid artery) by ultrasonography. In addition, A-IMT measurement was performed by abdominal ultrasonography. Statistically significant p value was set as <0.05 for all comparisons. Results In beta-thalassemia minor patients, native thiol, total thiol and native thiol / total thiol ratio were lower, and the IMA, disulfide / native thiol ratio and disulfide / total thiol ratios were higher than in healthy control group. A-IMT measurement was significantly higher in beta-thalassemia minor group than controls (1.46±0.37 vs 1.23±0.22 and p<0.001). When the parameters associated with A-IMT in univariate analysis were evaluated by multivariate linear regression analysis, A-IMT was positively related, and native thiol and total thiol levels were negatively and closely related to IMA (p<0.01). Conclusion We demonstrated, for the first time, that oxidative stress status increased with increased A-IMT, while C-IMT remained unchanged in beta-thalassemia minor patients.


Full text: Available Index: LILACS (Americas) Language: Portuguese Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2022 Type: Article Affiliation country: Turkey Institution/Affiliation country: Adana Health Practice and Research Center/TR / University of Y&#305;ld&#305;r&#305;m Beyaz&#305;t/TR

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Full text: Available Index: LILACS (Americas) Language: Portuguese Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2022 Type: Article Affiliation country: Turkey Institution/Affiliation country: Adana Health Practice and Research Center/TR / University of Y&#305;ld&#305;r&#305;m Beyaz&#305;t/TR