Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite
Braz. J. Pharm. Sci. (Online)
;
58: e20243, 2022. graf
Article
in English
| LILACS
| ID: biblio-1403682
ABSTRACT
Abstract In drug therapy, it is important to provide therapeutic levels of drug to the site of action and maintain them during the treatment. This work describes the in vitro release of alendronate from sodium alginate cross-linked Montmorillonite (MMT) composite beads. Effect of crosslinking cation, concentration of montmorillonite and media on encapsulation efficiencies, and release profiles of alendronate were studied. Beads were characterized using equilibrium swelling ability study, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Energy-dispersive x-ray spectroscopy (EDX) and scanning electron microscopy (SEM). Results indicate that addition of montmorillonite increases the encapsulation efficiencies and slows down the release rates significantly.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Bentonite
/
Alendronate
/
Alginates
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2022
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Islamic Azad University/IN
/
Islamic Azad University/IR
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