Your browser doesn't support javascript.
loading
Repurposing of Metformin for the prevention and treatment of Tuberculosis
Vyas, Navya; Punchathidil, Rakhi; Swain, Ansuman; Shakeer, Irfan; Reddy, Badikol Shrikar; Manu, Mohan Kamalanivas; Miraj, Sonal Sekhar.
  • Vyas, Navya; Manipal Academy of Higher Education. Prasanna School of Public Health. Department of Health Policy. Manipal. IN
  • Punchathidil, Rakhi; Manipal Academy of Higher Education. Prasanna School of Public Health. Department of Health Policy. Manipal. IN
  • Swain, Ansuman; Manipal Academy of Higher Education. Prasanna School of Public Health. Department of Health Policy. Manipal. IN
  • Shakeer, Irfan; Manipal Academy of Higher Education. Prasanna School of Public Health. Department of Health Policy. Manipal. IN
  • Reddy, Badikol Shrikar; Manipal Academy of Higher Education. Manipal College of Pharmaceutical Sciences. Department of Pharmacy Practice. Manipal. IN
  • Manu, Mohan Kamalanivas; Manipal Academy of Higher Education. Prasanna School of Public Health. Manipal Center for Infectious Diseases. Manipal. IN
  • Miraj, Sonal Sekhar; Manipal Academy of Higher Education. Prasanna School of Public Health. Manipal Center for Infectious Diseases. Manipal. IN
Braz. J. Pharm. Sci. (Online) ; 58: e20422, 2022. tab, graf
Article in English | LILACS | ID: biblio-1403684
ABSTRACT
Abstract The bidirectional relationship between tuberculosis (TB) and diabetes mellitus (DM) is a major concern for medical professionals and epidemiologists as DM affects the severity, progress and outcome of TB and vice versa. Patients affected with TB have a higher rate of morbidity, treatment failure and mortality. Likewise, DM triples the risk of contracting TB and therefore poses a threat to the progress made in the reduction of TB incidence. Hence, it is pivotal to address both the diseases keeping in mind the each other. It is known that adjunct therapy with immunomodulatory drugs can enhance TB immunity among diabetic patients. Metformin, a commonly used anti-diabetic drug with adenosine monophosphate-activated protein kinase (AMPK) activation property, has shown the capacity to reduce the growth of Mycobacterium tuberculosis within the cell. This drug inhibits the mitochondrial complex and possesses anti-inflammatory action. Therefore, Metformin can be considered as an ideal molecule for host-directed or host-targeted therapy for TB.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Protein Kinases / Tuberculosis Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: India Institution/Affiliation country: Manipal Academy of Higher Education/IN

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Protein Kinases / Tuberculosis Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: India Institution/Affiliation country: Manipal Academy of Higher Education/IN