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Chemical study of Adenocalymma axillarum crude leaf extract and isolated compounds
Andrade, João Paulo Campos; Alves, Osvaine Junior Alvarenga; Costa, Marian Caroline; Gimenez, Valéria Maria Melleiro; Squarisi, Iara Silva; Nicolella, Heloiza Diniz; Pagotti, Mariana Cintra; Tavares, Denise Crispim; Cunha, Wilson Roberto; Silva, Márcio Luís Andrade e; Januario, Ana Helena; Magalhães, Lizandra Guidi; Pauletti, Patrícia Mendonça.
  • Andrade, João Paulo Campos; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Alves, Osvaine Junior Alvarenga; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Costa, Marian Caroline; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Gimenez, Valéria Maria Melleiro; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Squarisi, Iara Silva; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Nicolella, Heloiza Diniz; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Pagotti, Mariana Cintra; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Tavares, Denise Crispim; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Cunha, Wilson Roberto; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Silva, Márcio Luís Andrade e; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Januario, Ana Helena; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Magalhães, Lizandra Guidi; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
  • Pauletti, Patrícia Mendonça; University of Franca. Center for Research in Exact and Technological Sciences. Franca. BR
Braz. J. Pharm. Sci. (Online) ; 58: e20278, 2022. tab, graf
Article in English | LILACS | ID: biblio-1403705
ABSTRACT
Abstract Adenocalymma axillarum (K.Schum.) L.G. Lohmann is a liana belonging to the family Bignoniaceae. In traditional medicine, the genus Adenocalymma is used to treat fever, skin ailments, and body, joint, and facial muscle pains, and it is also applied as cosmetic. Biological assays conducted with the A. axillarum crude leaf ethanol extract have indicated leishmanicidal activity and absence of cytotoxicity. This study aimed to analyze the A. axillarum leaf ethanol crude extract by high-performance liquid chromatography-high-resolution mass spectrometry- diode array detector (HPLC-HRMS-DAD) and to evaluate the leishmanicidal and cytotoxic activities of this crude extract, its fractions, and isolated compounds. HPLC-HRMS-DAD analysis of this extract revealed that it consisted mainly of flavonoids, with nine major compounds. Extract purification yielded 4-hydroxy-N-methylproline, 6-β-hydroxyipolamiide, quercetin-3-O-robinobioside, hyperin, isorhamnetin-3-O-robinobioside, and 3'-O-methylhyperin, which were identified by Nuclear Magnetic Resonance. The isolated compounds were inactive against Leishmania amazonensis promastigotes and human lung fibroblast cells.
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Full text: Available Index: LILACS (Americas) Main subject: Mass Spectrometry / Magnetic Resonance Spectroscopy / Chromatography, High Pressure Liquid / Plant Leaves / Complex Mixtures / Leishmania Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of Franca/BR

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Full text: Available Index: LILACS (Americas) Main subject: Mass Spectrometry / Magnetic Resonance Spectroscopy / Chromatography, High Pressure Liquid / Plant Leaves / Complex Mixtures / Leishmania Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of Franca/BR