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Phytochemical profile, evaluation of antimicrobial and antioxidant activity in vitro of the hydroalcoholic extract of two species of the genus Cyperus (Cyperaceae)
Bezerra, José Jailson Lima; Nascimento, Ticiano Gomes do; Kamiya, Regianne Umeko; Prata, Ana Paula do Nascimento; Medeiros, Patrícia Muniz de; Silva, Sâmia Andrícia Souza da; Melo, Nathaly Esperidião de.
  • Bezerra, José Jailson Lima; Universidade Federal de Alagoas. Engenharias e Ciências Agrárias. Rio Largo. BR
  • Nascimento, Ticiano Gomes do; Universidade Federal de Alagoas. Instituto de Ciências Farmacêuticas. Maceió. BR
  • Kamiya, Regianne Umeko; Universidade Federal de Alagoas. Instituto de Ciências Biológicas e da Saúde. Maceió. BR
  • Prata, Ana Paula do Nascimento; Universidade Federal de Alagoas. Engenharias e Ciências Agrárias. Rio Largo. BR
  • Medeiros, Patrícia Muniz de; Universidade Federal de Alagoas. Engenharias e Ciências Agrárias. Rio Largo. BR
  • Silva, Sâmia Andrícia Souza da; Universidade Federal de Alagoas. Instituto de Ciências Farmacêuticas. Maceió. BR
  • Melo, Nathaly Esperidião de; Universidade Federal de Alagoas. Instituto de Ciências Biológicas e da Saúde. Maceió. BR
Braz. J. Pharm. Sci. (Online) ; 58: e20205, 2022. tab, graf
Article in English | LILACS | ID: biblio-1403727
ABSTRACT
Abstract Several factors contribute to the resistance of some pathogenic microorganisms and this fact requires the search for new therapeutic alternatives. The genus Cyperus (family Cyperaceae) groups species that present chemical compounds of pharmacological interest, mainly with antimicrobial action. Thus, the present work was carried out to investigate the antimicrobial activities, antioxidants and the phytochemical profile of Cyperus articulatus L. and Cyperus iria L. Hydroalcoholic extracts (11, vv) of the aerial and underground parts of these species were used to analyze the total phenol content and to evaluate the in vitro antioxidant activity against the DPPH (2,2-diphenyl-1-picrylhydrazyl). The ethyl acetate and chloroform phases resulting from liquid-liquid partitioning of C. articulatus and C. iria extracts were evaluated in antimicrobial assays and subject to high performance liquid chromatography (HPLC-DAD) analysis. The chromatograms obtained by HPLC-DAD allowed us to identify four compounds chlorogenic acid, catechin, quercetin, and quercitrin. The hydroalcoholic extracts of C. articulatus and C. iria showed a weak antioxidant activity with IC50 of 395.57 and 321.33 µg/mL (aerial parts), and 1,114.01 and 436.82 µg/mL (underground parts), respectively. Regarding antimicrobial activity, the chloroform phase of C. iria showed the best result at the concentration of only 31.2 µg/mL against the pathogens Candida albicans and Staphylococcus aureus. The ethyl acetate phases of the aerial parts of C. articulatus and C. iria did not show antimicrobial activity
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Full text: Available Index: LILACS (Americas) Main subject: Cyperaceae / Cyperus / Phytochemicals / Anti-Infective Agents / Antioxidants Type of study: Prognostic study Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Alagoas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Cyperaceae / Cyperus / Phytochemicals / Anti-Infective Agents / Antioxidants Type of study: Prognostic study Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Alagoas/BR