Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals
Clinics
;
77: 100107, 2022. tab
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1404330
ABSTRACT
Abstract Background:
This study aimed to evaluate the associations between Lipoprotein (a) ‒ Lp(a) levels and carotid Intima-Media Thickness (cIMT) and with carotid plaques in healthy subjects because of previous contradictory data.Methods:
A total of 317 healthy normolipidemic subjects (20‒77 years old) were selected. The cIMT and atherosclerotic plaques were determined by B-mode ultrasonography. Mann-Whitney tests were performed to compare the groups according to Lp(a) levels and to explore the associations between Lp(a), carotid plaques, and cIMT, logistic and linear regression analyses were performed.Results:
Studied population (51% females, median age 43 years old) presented carotid plaques and cIMT ≥ 0.9 mm in 23% and 18% of the participants, respectively. The group with Lp(a) levels > 30 mg/dL presented significantly higher age and atherosclerotic plaques. Indeed, multivariate linear regression analysis showed a significant association between Lp(a), age, and race. On the other hand, logistic regression analysis demonstrated that the subjects with Lp(a) > 30 mg/dL have a significantly high risk of carotid plaques.Conclusion:
The data from the present study indicate that Lp(a) levels above 30 mg/dL contribute to the development of carotid plaques even in apparently healthy participants.
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2022
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Pontifical Catholic University of Campinas/BR
/
Universidade Estadual de Campinas/BR
/
Universidade de Sao Paulo/BR
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