Performance of 68Ga-labeled prostate-specific membrane antigen ligand positron emission tomography/computed tomography in the diagnosis of primary prostate cancer: a systematic review and meta-analysis
Int. braz. j. urol
; 48(6): 891-902, Nov.-Dec. 2022. tab, graf
Article
in En
|
LILACS-Express
| LILACS
| ID: biblio-1405170
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Objective:
To explore the feasibility of 68Ga-PSMA PET/CT in diagnosing primary prostate cancer. Materials andMethods:
Embase, PubMed and Cochrane Library databases were searched for studies published before July 2020. The studies that used 68Ga-PSMA PET/CT for detecting primary prostate cancer, and pathological biopsy as the reference standard were included. The selecting process used preferred reporting items for systematic reviews and meta-analyses (PRISMA). The quality of enrolled studies was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool.Results:
According to our search strategy, 9 studies were included for analysis. A total of 547 patients with primary prostate cancer and 443 lesion segments that underwent 68Ga-PSMA PET/CT scans were included and their pathological biopsies were compared. The results of these studies showed some differences. For instance, the lowest sensitivity of 68Ga-PSMA PET/CT in diagnosing primary prostate cancer was 67%, while the highest sensitivity recorded was 97%.Conclusions:
Compared with conventional imaging examinations, 68Ga-PSMA PET/CT had higher sensitivity and specificity in detecting primary prostate cancer. At present, most of the studies that used 68Ga-PSMA PET/CT for detecting prostate cancer are retrospective studies. Based on its advantage of high detection rate, the use of 68Ga-PSMA PET/CT in the detection of primary prostate cancer is worthy of promotion.
Full text:
1
Index:
LILACS
Type of study:
Diagnostic_studies
/
Observational_studies
/
Systematic_reviews
Language:
En
Journal:
Int. braz. j. urol
Journal subject:
UROLOGIA
Year:
2022
Type:
Article
/
Project document