Cardiovascular Risk Factors in Children and Adolescents with Fontan Circulation
Int. j. cardiovasc. sci. (Impr.)
;
35(5): 618-624, Sept.-Oct. 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1405184
ABSTRACT
Abstract Background:
Long-term outcomes of patients with Fontan circulation are uncertain regarding the prevalence and role of risk factors (RFs) such as increased body mass index (BMI), arterial hypertension, and hypercholesterolemia.Objectives:
To describe the prevalence of RFs in patients with univentricular heart, with variable follow-up times.Methods:
This mixed cohort study was performed with 66 patients, who underwent blood count, fasting blood glucose, C-reactive protein (CRP), and lipid profile tests; systolic/diastolic blood pressure (SBP/DBP) measurements; and anthropometric and sociodemographic data collection. Cardiovascular RFs among first-degree relatives and physical activity habits were also assessed. Prevalence was described using proportions, with a 95% confidence interval. Continuous variables (height, weight, age, SBP, DBP) were described as means and standard deviations (m±SD). Associations between RFs were assessed using chi-squared or Fisher's exact tests. Spearman's correlation was used for analyzing CRP and the presence of 2 or more RFs. The Shapiro-Wilk test was used to check for data normality. Statistical significance considered p<0.05.Results:
In our population, 19.7% were overweight, mean SBP was 89.44±37.4, and mean DBP was 60.0±26.08. The most prevalent diseases in the interviewees' families were systemic arterial hypertension (30.3%), obesity (16.7%), and 2 or more cardiovascular RFs among first-degree relatives (13.8%). We observed a trend towards significance between the presence of 2 familial RFs and overweight, as well as a risk profile for cardiovascular disease. There was an association between the BMI percentile, the presence of 2 or more RFs (p<0.05), and CRP (p<0.01).Conclusions:
Overweight is common in patients with univentricular heart, being related to more than 2 cardiovascular RFs among first-degree relatives; physical inactivity and changes in lipid profiles are also frequent.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Etiology study
/
Observational study
/
Risk factors
Language:
English
Journal:
Int. j. cardiovasc. sci. (Impr.)
Journal subject:
Cardiology
Year:
2022
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Universitária de Cardiologia/BR
/
Instituto de Cardiologia/BR
/
Pontifícia Universidade Católica do Rio Grande do Sul/BR
/
Universidade Federal de Ciências da Saúde de Porto Alegre/BR
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