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Serum Syndecan-1 levels in patients with immunoglobulin A vasculitis in children
Jia, Xinyi; Zhu, Zhenya; Miao, Jing; Zhang, Linqian; Li, Xiaobing; Bao, Yunguang; Jiang, Mizu.
  • Jia, Xinyi; Zhejiang University. School of Medicine. National Clinical Research Center. Hangzhou. CN
  • Zhu, Zhenya; Zhejiang University. School of Medicine. National Clinical Research Center. Hangzhou. CN
  • Miao, Jing; Zhejiang University. School of Medicine. National Clinical Research Center. Hangzhou. CN
  • Zhang, Linqian; Zhejiang University. Jinhua Hospital. Jinhua Municipal Central Hospital. Jinhua. CN
  • Li, Xiaobing; Zhejiang University. Jinhua Hospital. Jinhua Municipal Central Hospital. Jinhua. CN
  • Bao, Yunguang; Zhejiang University. Jinhua Hospital. Jinhua Municipal Central Hospital. Jinhua. CN
  • Jiang, Mizu; Zhejiang University. School of Medicine. National Clinical Research Center. Hangzhou. CN
J. pediatr. (Rio J.) ; 98(5): 526-532, Sept.-Oct. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1405487
ABSTRACT
Abstract Objective The aim of this study was to evaluate the serum Syndecan-1 (SDC-1) levels in patients with immunoglobulin-A vasculitis (IgAV) in children and its relation with gastrointestinal involvements. Methods Sixty-eight children with IgAV and 48 healthy children were enrolled in this cross-sectional study. Clinical and related laboratory data were collected from a computerized hospital database. Serum SDC-1 was collected on admission prior to treatment. Results Forty-eight patients fully met the IgAV diagnostic criteria at admission (IgAV group), 20 patients with rash only and diagnosed IgAV during hospitalization (Purpura group). In IgAV group, 30 patients with gastrointestinal involvements (IgAV-GI group) and 18 patients without gastrointestinal involvements (IgAV-NGI group). SDC-1 serum levels were significantly higher in the IgAV group (86.37 ng/mL (IQR 59.16-117.14 ng/mL)) than in the controls (20.37 ng/mL (IQR 15.52-26.45 ng/mL)) and the Purpura group (32.66 ng/mL (IQR 14.87-49.89 ng/mL)). Additionally, SDC-1 (OR = 1.08) was independently associated with IgAV with a cut-off value (sensitivity and specificity) of 66.55 ng/mL (68.8%, 95.0%), and the area under the curve was 0.908. The serum SDC-1 levels of the IgAV-GI group (106.92 ± 50.12 ng/mL) were significantly higher than those in the IgAV-NGI group (67.52 ± 17.59 ng/mL). Logistic regression analysis showed that SDC-1 (OR = 1.03) was independently associated with IgAV-GI with a cut-off value of 89.39 ng/mL. Conclusions SDC-1 serum levels may mirror vascular endothelium injury and mucosal damage in IgAV. Its applicability as a surrogate biomarker in IgAV remains to be determined.


Full text: Available Index: LILACS (Americas) Type of study: Observational study / Prognostic study / Risk factors Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2022 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Zhejiang University/CN

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Full text: Available Index: LILACS (Americas) Type of study: Observational study / Prognostic study / Risk factors Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2022 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Zhejiang University/CN