Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports
J. venom. anim. toxins incl. trop. dis
;
28: e20220020, 2022. tab
Article
in English
| LILACS, VETINDEX
| ID: biblio-1405508
ABSTRACT
Peripheral facial paralysis (PFP) has been shown to be a neurological manifestation of COVID-19. The current study presents two cases of PFP after COVID-19, along with a rapid review of known cases in the literature. Both case reports were conducted following CARE guidelines. We also performed a systematic review of PFP cases temporally related to COVID-19 using PubMed, Embase, and Cochrane Library databases on August 30, 2021, using a rapid review methodology. The two patients experienced PFP 102 and 110 days after COVID-19 symptom onset. SARS-CoV-2 RNA was detected in nasal samples through reverse-transcription real-time polymerase chain reaction (RT-qPCR) testing. Anosmia was the only other neurological manifestation. PFP was treated with steroids in both cases, with complete subsequent recovery. In the rapid review, we identified 764 articles and included 43 studies. From those, 128 patients with PFP were analyzed, of whom 42.1% (54/128) were male, 39.06% (50/128) female, and in 23 cases the gender was not reported. The age range was 18 to 59 (54.68%). The median time between COVID-19 and PFP was three days (ranging from the first symptom of COVID-19 to 40 days after the acute phase of infection). Late PFP associated with COVID-19 presents mild symptoms and improves with time, with no identified predictors. Late PFP should be added to the spectrum of neurological manifestations associated with the long-term effects of SARS-CoV-2 infection as a post COVID-19 condition.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Facial Paralysis
/
COVID-19
/
Neuromuscular Diseases
Type of study:
Prognostic study
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Year:
2022
Type:
Article
Institution/Affiliation country:
Central Laboratory of Public Health (LACEN) of Mato Grosso do Sul/BR
/
Federal University of Mato Grosso do Sul/BR
/
Universidade Federal do Mato Grosso do Sul/BR
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