Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose
Motriz (Online)
;
28: e10220005522, 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1406006
ABSTRACT
Abstract Aim:
We investigated the effects of continuous or interval aerobic exercise training on vascular reactivity of female rats fed with fructose.Methods:
Female Wistar rats (8-wk old) were divided into sedentary (SD), continuous training (CTR), and interval training (ITR). Moderate intensity training protocols consisted of running 3 days/week for 7 weeks. CTR ran 40 min at 30%-40% of the maximal speed (MS) and TRI consisted of 7 sets of 1 min at 70% of MS followed by 3 min at 35% of MS. Animals were fed with standard chow and fructose (10%) in drinking water. Concentration-response curves to acetylcholine and phenylephrine, and oxidative stress biomarkers, were determined in the aorta. Body weight gain, visceral fat, and plasma triglycerides and glucose were also evaluated.Results:
Endothelium-dependent relaxation was significantly increased by both exercise regimens (CTR Emax = 85 ± 6% and ITR Emax = 84 ± 1%) compared to sedentary rats (SD Emax = 62 ± 5%). The contractile maximal response was not different but phenylephrine potency was increased in CTR (pEC50 8.41 ± 0.19) and reduced in ITR (pEC50 7.06 ± 0.11) compared to SD (pEC50 7.77 ± 0.08). In addition, the generation of superoxide was lower in trained groups as compared with sedentary (about −28% in CTR and −22% in ITR). TBARS and nitrate/nitrite levels were not modified. Compared to the SD group, ITR gained 39% less body weight and CTR has 29% less visceral fat. Glucose and triglycerides were not modified.Conclusion:
CTR and ITR, carried out 3 days/week, were efficient to improve endothelium-dependent relaxation and reduce superoxide generation in the aorta from female rats fed with fructose.
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
Motriz (Online)
Journal subject:
EducaÆo F¡sica e Treinamento
/
Medicina Esportiva
/
Medicina F¡sica e ReabilitaÆo
Year:
2022
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Escola de Enfermagem de Ribeirão Preto/BR
/
Universidade Estadual Paulista Júlio de Mesquita Filho/BR
/
Universidade de São Paulo/BR
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