Temporal progression of sepsis on critical care COVID-19 patients: a retrospective cohort study
Rev. Assoc. Med. Bras. (1992, Impr.)
;
68(10): 1458-1463, Oct. 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1406549
ABSTRACT
SUMMARY OBJECTIVE:
This study aimed to describe sepsis progression in critical COVID-19 patients using the SOFA score and investigate its relationship with mortality.METHODS:
Three researchers collected and analyzed retrospective clinical and laboratory data found in electronic health records from all patients admitted to a severe COVID-19 exclusive intensive care unit from March 2020 to October 2020. Mixed-effect logistic regression was used to evaluate SOFA (Sepsis-3) score variables as mortality prediction markers, while Kaplan-Meier survival curves were used to compare mortality between groups of patients. Cox proportional hazard models were used to further stratify mortality association between variants.RESULTS:
A total of 73 patients were included. Temporal COVID-19-related sepsis progression analysis indicates difference in degrees and timing between different organ dysfunction over time. Sepsis-3 Cardiovascular Dysfunction characterized by severe hypotension added to the use of any vasopressor drugs was the only parameter associated with in-hospital death during the first 5 days of hospital admission (OR 2.19; 95%CI 1.14-4.20; p=0.01).CONCLUSION:
Increased Sepsis-3 Cardiovascular Dysfunction score, characterized as hypotension associated with the use of vasopressor drugs in the first days of intensive care unit stay, is related to higher mortality in COVID-19 patients and may be a useful prognostic prediction tool.
Full text:
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Index:
LILACS (Americas)
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicine
Year:
2022
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Santa Casa de Misericórdia de Porto Alegre/BR
/
Universidade Federal de Ciências da Saúde de Porto Alegre/BR
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