Evaluation of platelet indices and pro-inflammatory cytokines in type 2 diabetic patients with retinopathy
Rev. Assoc. Med. Bras. (1992, Impr.)
;
68(11): 1537-1541, Nov. 2022. tab
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1406579
ABSTRACT
SUMMARY OBJECTIVE:
The aim of this study was to investigate whether platelet parameters and pro-inflammatory cytokines associated with platelet activation could be surrogate markers of the diabetic retinopathy stages in type 2 diabetic patients.METHODS:
This prospective case-control study included 108 type 2 diabetes mellitus patients and 48 healthy controls. After fundoscopic examination, patients were divided into three groups no retinopathy, nonproliferative diabetic retinopathy, or proliferative retinopathy. Platelet selectin, interleukin-1alpha, and interleukin-6 values were measured by the enzyme-linked immunosorbent assay method. Homeostatic Model Assessment for Insulin Resistance formula was used to assess insulin resistance in patients.RESULTS:
Mean platelet volume was lower and interleukin-1alpha was higher in the patients compared to the healthy controls (p=0.046 and p<0.001, respectively). In addition, a positive correlation between the platelet distribution width and HbA1C levels was observed in the patients (r=0.334, p<0.001).CONCLUSION:
In the studies evaluating the utility of platelet indices and the associated cytokines in diabetic retinopathy, there is a need for the standardization of the measurements. All medications that can affect platelet activation should be taken into consideration.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicine
Year:
2022
Type:
Article
/
Project document
Affiliation country:
Turkey
Institution/Affiliation country:
Bayındır Içerenköy Hastanesi/TR
/
Sakarya University Training and Research Hospital/TR
/
University of Health Sciences/TR
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