The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
Rev. Inst. Med. Trop. São Paulo (Online)
;
64: e64, 2022. graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1406891
ABSTRACT
ABSTRACT Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Etiology study
Language:
English
Journal:
Rev. Inst. Med. Trop. São Paulo (Online)
Journal subject:
Medicina Tropical
Year:
2022
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
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